20.500.12556/DiRROS-27554 Effect of PCSK9 inhibitors on regulators of lipoprotein homeostasis, inflammation and coagulation Background: PCSK9 inhibitors (PCSK9i) represent a newer form of atherosclerosis treatment. Inflammation and haemostasis are key processes in the development of atherosclerosis. In this study, we investigated the influence of therapy with PCSK9i in patients with coronary artery disease (CAD) on regulators for lipoprotein homeostasis, inflammation and coagulation. Methods: Using quantitative polymerase chain reaction (qPCR), we measured the expression of the genes involved in lipoprotein homeostasis, namely for sterol regulatory element-binding protein 1 (SREBP1), SREBP2, low-density lipoprotein receptor (LDLR), hepatic lipase type C (LIPC), LDLR-related protein 8 (LRP8), and the genes associated with inflammation and coagulation, such as cluster of differentiation (CD) 36 (CD36), CD63, and CD14 in 96 patients with CAD and 25 healthy subjects. Results: Significant differences in the expression of the investigated genes between patients and healthy controls were found. Treatment with PCSK9i also resulted in significant changes in the expression of all studied genes. Conclusions: We established that PCSK9i may have a significant effect on the gene expression of lipid regulators, inflammatory markers, and coagulation parameters, independent of their lipolytic effect. PCSK9 inhibitors lipid regulators inflammation coagulation coronary artery disease zaviralci PCSK9 regulatorji lipidov koagulacija bolezen koronarnih arterij true false true Angleški jezik Slovenski jezik Neznano 2026-02-12 13:58:13 2026-02-12 13:58:14 2026-02-13 03:50:54 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 3. 2. 2025; 15 str. issue 2, [article no.] 294 Vol. 13 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-002:616.132.2 2227-9059 10.3390/biomedicines13020294 224843267 RAZ_Lunar_Patricija_2025.pdf RAZ_Lunar_Patricija_2025.pdf 1 12A68D4050D861AFF9814C597F1765A5 6a19ceb175934673a723c3b06799c84104ad88179de3b61d3975f776cc0cbf04 d5de7ba1-0812-11f1-bcbc-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40362 https://www.mdpi.com/2227-9059/13/2/294 1 80f1fb2f-0812-11f1-bcbc-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40361 Univerzitetni klinični center Ljubljana 0 0 0