20.500.12556/DiRROS-27552 The role of cytokines and chemokines as biomarkers of disease activity in idiopathic nephrotic syndrome in children This study investigates the association of plasma concentrations of various cytokines and chemokines with the disease activity of idiopathic nephrotic syndrome (INS) in children in Slovenia. (2) In a prospective single-center study lasting 18 months, we took sequential plasma samples from children with INS at disease onset or relapse (prior to corticosteroid (CS) therapy), at remission, and after discontinuation of CS therapy. The Olink®Target 48 Cytokine Panel was applied to analyze 45 analytes in the plasma samples, adhering to the manufacturer’s protocol. We performed a statistical analysis with a paired samples analysis with a t-test as well as with a non-parametric Wilcoxon correction test. (3) We included 18 pediatric patients with INS in the study. We demonstrated statistically significant differences in the concentrations of CSF1, IL4, FLT3LG, CCL19, and MMP12 in the patients at disease onset or relapse compared to those in remission, differences in the concentrations of CSF1 and IL17F in the patients at disease onset or relapse compared to those in remission after CS treatment, and differences in the concentrations of CCL19, MMP12, and CCL13 in the patients in remission compared to those in remission after CS treatment. (4) The findings support potential roles of certain cytokines and chemokines, especially CSF1, CCL19, and MMP12, in influencing the disease activity of INS. cytokines chemokines idiopathic nephrotic syndrome children kemokini idiopatski nefrotski sindrom otroci true false true Angleški jezik Slovenski jezik Neznano 2026-02-12 13:45:35 2026-02-12 13:45:36 2026-02-13 03:50:53 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis z dne 3. 2. 2025; 11 str. iss. 2, [article no.] 7 Vol. 47 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61:616.611-053.2 1467-3045 10.3390/cimb47020077 224866819 RAZ_Kopac_Matjaz_2025.pdf RAZ_Kopac_Matjaz_2025.pdf 1 B98A76B3E4BCA06ED730AB65D8BB4B81 13cafdab53fbdc7eb868e5318d515b67edecc540387c749bcb272782cacbb4df 3f7d44b9-0811-11f1-bcbc-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40358 https://www.mdpi.com/1467-3045/47/2/77 1 c33f198d-0810-11f1-bcbc-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40356 Univerzitetni klinični center Ljubljana 0 0 0