20.500.12556/DiRROS-27533 The influence of periodontal disease and periodontal treatment on colorectal cancer Background: Periodontal disease (PD) is associated with more than 50 diseases and conditions, including colorectal cancer. The study aimed to investigate if periodontal treatment influences the blood levels of C-reactive protein (CRP) in colorectal cancer patients. In addition, the aim was to isolate periodontal pathogenic bacteria Fusobacterium nucleatum (FN) and Porphyromonas gingivalis (PG), which are most linked to colorectal cancer (CRC), from the mucosa of the cancer-affected intestine. Patients and methods: To assess the effect of periodontal treatment on colorectal cancer, we measured the CRP levels in the blood during cancer therapy on the day of the initial examination by the oncological surgeon, two days following surgery, and at the first follow-up appointment. We compared the CRP levels between two groups: the group of subjects who underwent periodontal treatment and the patients who did not receive periodontal disease treatment. An attempt was made to isolate the periodontal pathogenic bacteria FN and PG from the mucosa of the cancerous tissue in the colon by using quantitative culture. Results We found no statistically significant difference between the groups in the initial CRP measurements before starting cancer treatment. There was no statistically significant difference between the groups in the CRP measurements taken 1st and 2nd day after surgery and at the follow-up appointment. We could not isolate periodontal pathogenic bacteria FN and PG from cancer-altered intestine mucosa using the quantitative culture method. Conclusions Our study did not find any correlation between periodontal treatment and CRC. periodontal disease colorectal cancer periodontal treatment fusobacterium nucleatum porphyromonas gingivalis C-reactive protein parodontalna bolezen kolorektalni rak parodontalno zdravljenje C-reaktivni protein true false true Angleški jezik Slovenski jezik Neznano 2026-02-11 14:44:21 2026-02-11 14:44:22 2026-02-12 03:52:54 0000-00-00 00:00:00 2025 0 0 str. 589-596 no. 4 Vol. 59 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616.31 1318-2099 10.2478/raon-2025-0025 237242883 RAZ_Potocnik_Ursa_2025.pdf RAZ_Potocnik_Ursa_2025.pdf 1 04A41C5A7178DF17C49C48DFDF845A8C c1698605e449ecaa294621d1478fe7a6439bdd0800912329348ff691987213c2 e32ee14c-074f-11f1-bcbc-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40327 https://sciendo.com/article/10.2478/raon-2025-0025 1 c6d064c3-074f-11f1-bcbc-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40326 Univerzitetni klinični center Ljubljana 0 0 0