20.500.12556/DiRROS-26988 Inflammatory biomarkers as predictors of prognosis in patients after transcatheter aortic valve implantation Background: The expanding role of transcatheter aortic valve implantation (TAVI) highlights the need to identify factors influencing long-term outcomes. Systemic inflammatory response syndrome (SIRS) is a frequent post-procedural event that may adversely affect prognosis. Measurement of inflammatory biomarkers may improve the understanding of underlying mechanisms and refine patient risk stratification.Methods: This single-center, prospective cohort study, enrolled 62 consecutive patients undergoing TAVI, who were followed for up to 5 years. Blood samples were collected before TAVI, at 24 h and 3–6 months post-procedure. Changes in biomarker levels, predictors of SIRS, and inflammatory predictors of long-term outcomes were analyzed.Results: SIRS developed in 45% of patients. Significant temporal changes were observed in hs-CRP, TNF-α, sST2/IL-33, IL-10, and IL-2 levels, irrespective of baseline or procedural characteristics. The development of SIRS was associated with a higher risk of all-cause mortality or unplanned hospitalization at 5 years (HR 3.07, 95% CI 1.57–6.00; p = 0.001). Baseline hs-CRP (HR 1.21, 95% CI 1.09-1.35; p < 0.001) and IFN-γ (HR 1.22; 95% CI 1.09–1.36; p < 0.001) levels were predictive of adverse outcomes. In multivariable Cox analysis, these associations remained, though findings should be interpreted cautiously given the limited sample size.Conclusions: SIRS is a common post-TAVI phenomenon and may be linked to long-term outcomes. Elevated pre-procedural hs-CRP and IFN-γ levels were associated with higher risk for adverse events, suggesting they may serve as exploratory biomarkers for risk stratification in this population. systemic inflammatory response syndrome SIRS transcatheter aortic valve implantation high sensitivity CRP hs-CRP interferon gamma IFN-γ inflammatory biomarkers true false true Angleški jezik Ni določen Neznano 2026-01-28 11:25:18 2026-01-28 11:25:19 2026-01-31 04:11:10 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 28. 1. 2026; str. 1-11 Vol. 12, [article no.] 1722293 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 2297-055X 10.3389/fcvm.2025.1722293 266429443 RAZ_Vitez_Luka_2026.pdf RAZ_Vitez_Luka_2026.pdf 1 6EB29A27A7992D19B7C9D2C0B6DF9354 661a3555d654c43f2c05ee6d96b67a3c903a212a45c8f2f1e14a0e650d2d1e9a c1593a1a-fc33-11f0-a15d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=39595 https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1722293 0 cec7431a-fc33-11f0-a15d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=39596 Univerzitetni klinični center Ljubljana 0 0 0