20.500.12556/DiRROS-26986 The combined effects of artificial gravity, temperature, and hypoxia on haemodynamic responses and limb blood flow Under simultaneous environmental and gravitational stressors, integrated vascular responses maintain homeostatic balance via coordinated baro- and thermo-regulatory action. The effect of temperature and hypoxia at an elevated gravitational vector on the interaction of these systems was examined. Ten male participants experienced either cool (18.4 °C) or warm (29.1 °C) ambient temperatures in normoxia (partial pressure of oxygen, PIO2 = 133 mmHg) or hypoxia (PIO2 = 92 mmHg). Cardiovascular (heart rate, HR; arterial pressure, MAP; cardiac output, CO; stroke volume, SV; skin blood flow, SkBF) and thermoregulatory (skin temperature; core temperature) responses were monitored during standing (NG), and supine centrifugation at ground reaction forces (GRF) measured with a force platform at 1GRF and 2GRF. At 2GRF, warm and hypoxic conditions reduced the test duration by 16%. No differences were observed between NG and 1GRF in any variable; however, 2GRF significantly raised HR by 29.3% and MAP by 12.6%, and lowered SV by 22.2%. Warm condition significantly increased HR, and significantly decreased MAP and SV compared to the cool condition, by 17.8%, 6.1%, and 5.8%, respectively. Hypoxia had no effect on any variable. Arm SkBF significantly decreased by 33.3% with increasing artificial gravity, whereas leg SkBF increased by 38.7%. Higher ambient temperatures had no effect on leg SkBF, but significantly increased arm SkBF by 38.7%. Human tolerance to passive centrifugation is significantly lower at 2GRF, and further affected by the ambient conditions. Haemodynamic and leg SkBF responses in higher temperature and Gz conditions were frequently unable to prevent pre-syncopal symptoms. Finally, arm SkBF was modulated by both baroreflex and thermoregulation, and the baroreflex alone in leg SkBF. microvascular blood flow thermoregulation baroreflex artificial gravity pretok krvi termoregulacija umetna gravitacija true false true Springer-Verlag Nemčija Angleški jezik Slovenski jezik © The Author(s) 2025 Neznano 2026-01-28 10:41:41 2026-01-28 10:41:42 2026-01-31 04:10:54 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Soavtorji iz Slovenije: Urša Ciuha, Adam C. McDonnell, Igor B. Mekjavić; Opis vira z dne 14. 5. 2025; str. [1-15] iss. Vol. 125 [in press] 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-08-21 2025-03-04 2025-04-02 612 1439-6327 10.1007/s00421-025-05773-7 235832067 https://link.springer.com/article/10.1007/s00421-025-05773-7 1 908d2541-fc2d-11f0-a15d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=39589 RAZ_Fisher_Jason_T._2025.pdf RAZ_Fisher_Jason_T._2025.pdf 1 46E7E7C5AFCF5AB7E017068FFFC5A309 91ab40c3a40fea046d3c0631e187f6b4bf16ef0615670f302824872ed070a6ad 21513471-fc2e-11f0-a15d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=39592 Institut Jožef Stefan 0 0 0