20.500.12556/DiRROS-25694 Anteromedial globus pallidus internus deep brain stimulation for Gilles de la Tourette syndrome a two-case report and review of the literature Background: Gilles de la Tourette syndrome is a neurobehavioral disorder that typically begins in childhood, subsides during puberty, and may reappear in adolescence. Treatment is primarily conservative, involving psychological and pharmacological therapy. Patients who do not respond to conservative therapy may be treated with deep brain stimulation, although this remains an experimental treatment. Methods: In this two-case report we present the first two cases of patients with Gilles de la Tourette syndrome in Slovenia treated with deep brain stimulation of the anteromedial globus pallidus internus. Results: Over an 18-month follow-up period, we observed an improvement in both cases. In the first case, the Yale Global Tic Severity Scale score decreased from 71 (17 for motor tics, 14 for phonic tics, and 40 on the impairment scale) to 44 points (12 motor, 12 phonic, and 20 impairment). In the second case, the score decreased from 72 (16 motor, 16 phonic, and 40 impairment) to 38 points (8 motor, 10 phonic, and 20 impairment). Conclusions: Deep brain stimulation could be a promising treatment for this disorder. However, further research is needed to determine the most suitable patients and targets. deep brain stimulation Gilles de la Tourette syndrome anteromedial globus pallidus internus globoka možganska stimulacija sindrom Gilles de la Tourette anteromedialni del globus pallidus internus true false true Angleški jezik Slovenski jezik Neznano 2026-01-27 13:00:18 2026-01-27 13:00:18 2026-01-28 04:15:08 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 27. 1. 2026; str. 1-9 issue 2, [article no.] 21 Vol. 18 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 2035-8377 10.3390/neurolint18020021 266297091 RAZ_Felbabic_Tomislav_2026.pdf RAZ_Felbabic_Tomislav_2026.pdf 1 28CB63AC8742B9DA742F7091BE6DA67E 616687b235c845787fa9161e10bbbc300222f918f9f8aaa8b5ff3df37c88bdc5 324807ce-fb78-11f0-a15d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=39002 https://www.mdpi.com/2035-8377/18/2/21 0 52536e92-fb78-11f0-a15d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=39003 Univerzitetni klinični center Ljubljana 0 0 0