20.500.12556/DiRROS-25399 Acute human bocavirus 1 infection in children hospitalized for acute bronchiolitis a 2-year prospective study Background: The objective of this prospective study was to assess the proportion and clinical consequences of human bocavirus 1 (HBoV1) replication in children hospitalized for acute bronchiolitis (AB) with HBoV1 DNA in the nasopharynx (NP). Methods: For this purpose, we detected HBoV1 DNA and mRNA (evidence of viral replication and viable virus) in NP in cases and healthy control children. This research allowed us to distinguish active HBoV1 infections from inactive ones. Results: HBoV1 DNA was detected in the NP of 37 of 307 patients with AB (12.1%) and 9 of 150 children in a healthy control group (6%) with a high codetection rate with other respiratory viruses in AB patients, 28 of 37 (75.7%). Only 9 of 37 HBoV1 DNA-positive NP swabs (24.3%) with high DNA load were also HBoV1 mRNA positive, moreover, HBoV1 DNA was also detected in the plasma of these patients. Conclusions: Based on the results of our study, we can conclude that children with AB acute HBoV1 infection has a high HBoV1 DNA load in NP samples together with detected HBoV1 mRNA and detected HBoV1 DNA in plasma. human bocavirus 1 infection children acute bronchiolitis true false true Angleški jezik Ni določen Neznano 2026-01-19 15:43:36 2026-01-19 15:43:37 2026-01-20 04:06:21 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 14. 1. 2025; str. 195-199 iss. 3 Vol. 44 Mar. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61 1532-0987 10.1097/INF.0000000000004613 222346499 RAZ_Ursic_Tina_2025.pdf RAZ_Ursic_Tina_2025.pdf 1 6CF4CCE4AF2ADF3EF9D4B1DD42878DDC fbd47dc5e971f53a7c7697f51dee9f9155106bef6c9c613daf9620038c35b9b2 6b92b934-f545-11f0-a15d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=38458 https://journals.lww.com/pidj/fulltext/2025/03000/acute_human_bocavirus_1_infection_in_children.2.aspx 1 3f12495d-f545-11f0-a15d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=38457 Univerzitetni klinični center Ljubljana 0 0 0