20.500.12556/DiRROS-25261 Psychological distress in young adults with well-controlled psoriasis Introduction: Psychological distress is common in psoriasis, but its prevalence and possible biological correlates in young adults with well-controlled disease remain unclear. In this study, we aimed to assess the presence of anxiety and depressive symptoms in young, well-treated psoriasis patients, who were primarily expected to have no or minimal psychological distress, and to explore potential associations with inflammatory and metabolic markers. Methods: In a cross-sectional cohort of 80 psoriasis patients (women/male: 45/35; mean age 38.7 ± 4.2 years) psychological symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS), with HADS-A and HADS-D subscales evaluating anxiety and depression symptoms. Exploratory associations with inflammatory cytokines and metabolic indices were examined using regression analyses and random forest machine-learning models. Results: Anxiety symptoms were identified only in 5 patients (women/male: 4/1; 6%), and depressive symptoms in 10 patients (women/male: 6/4; 12%). Affected individuals had clinically significant anxiety (HADS-A: 12/21) and borderline depressive symptoms (HADS-D: 10/21). No significant associations between HADS scores and inflammatory or metabolic markers were found. Exploratory random forest models tentatively identified IL-6, IL-23, FIB-4, HOMA-IR, and waist circumference as the strongest contributors to variance in depressive symptoms, while no clear contributors emerged for anxiety. Discussion: Anxiety and depressive symptoms can occur in well-treated young psoriasis patients. Although prevalence is low, their impact may be substantial. These findings indicate the potential importance of targeted psychological screening in this population. Associations with inflammatory and metabolic markers should be considered hypothesis-generating and warrant validation in larger, independent cohorts. psoriasis HADS depression anxiety treatment young patients psoriaza HADS depresija anksioznost zdravljenje mladi bolniki true false true Angleški jezik Slovenski jezik Neznano 2026-01-14 13:46:53 2026-01-14 13:46:53 2026-01-15 03:48:58 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dnhe 13. 1. 2026; str. 1-8 [article no.] 1753103 Vol. 16 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.5 1664-0640 10.3389/fpsyt.2025.1753103 264461059 RAZ_Merzel_Sabovic_Eva_Klara_2026.pdf RAZ_Merzel_Sabovic_Eva_Klara_2026.pdf 1 512B9146D695CA738B8DA5D6938B28E9 6ac7236618dc2d0a20f2667dca21d48802107d0575026f870b3fe73ba10b01bd 5e3f9d81-f147-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=38146 https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1753103/full 1 1bcc6ea4-f147-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=38143 Univerzitetni klinični center Ljubljana 0 0 0