20.500.12556/DiRROS-25245 Dual-energy x-ray absorptiometry derived body composition trajectories across adulthood reference values and associations with body roundness index and body mass index Background: Population-specific reference values are needed to accurately contextualise age-related changes in body composition. This study aimed to a) establish age- and sex-specific reference values and cut-points for a range of dual-energy x-ray absorptiometry (DXA) derived metrics of lean mass (LM), fat mass (FM) and bone mineral density (BMD), across adulthood in a large adult cohort; and b) determine the association between DXA-derived body composition, body roundness index (BRI), and body mass index (BMI). Methods: Cross-sectional data were collected from 10,033 men and women aged from 18 to 92 years. Whole-body DXA scans were performed, and a range of metrics were calculated for LM (total LM, arm LM, leg LM, appendicular lean mass: ALM, skeletal muscle index: SMI), FM (total FM: kg and %, FMI, android to gynoid: A/G ratio) and bone (BMD). Cut-points equivalent to Z-scores of 1.0e2.5 SDs from the mean of a young reference population were established for each body composition metric. Results: Detailed age- and sex-specific percentile curves were generated using the LMS method. Metrics of LM, central adiposity and BMD were higher in men, compared to women, whereas metrics of general FM accumulation were higher in women, compared to men. In both sexes, all LM metrics remained broadly stable during early and middle adulthood, after which progressively lower quantities were shown, whereas progressively higher FM metrics were shown from early adulthood through to late adulthood. In men, BMD was broadly stable across adulthood, whereas in women, markedly lower BMD was observed from the fifth decade of life. Significantly higher quantities of LM were shown across BMI categories, but not across BRI categories. The BRI was better correlated with FM%, FMI, and A/G ratio, compared to the BMI. Conclusion: The reference values presented herein may support the interpretation of body composition in public health settings and the identification of people who may benefit from intervention to improve musculoskeletal and metabolic health. The BRI better reflects DXA-derived body composition and may provide screening utility beyond that of the BMI. body shape bone fat mass muscle mass screening telesna oblika kost maščobna masa mišična masa presejanje true false true Angleški jezik Slovenski jezik The Authors Neznano 2026-01-14 11:26:49 2026-01-14 11:26:50 2026-01-15 03:48:52 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis z dne 14. 1. 2026; str. 137-146 Vol. 46 mar. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2025-03-01 616.7:612 1532-1983 10.1016/j.clnu.2025.02.001 264656899 26-01-14-Narici-264656899.pdf 26-01-14-Narici-264656899.pdf 1 0910CC46F6C2A09B5DD77CF4CBCCF319 edf1008b197b764367851a912e8932f08b3f57976fb58c1a68ee5d9c085a00ab a1c469bc-f133-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=38103 https://www.sciencedirect.com/science/article/pii/S0261561425000366?via%%203Dihub 1 8bfde51b-f133-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=38102 Znanstveno-raziskovalno središče Koper / Centro di Ricerche Scientifiche Capodistria 0 0 0