20.500.12556/DiRROS-25209 Potential of synergist ablation to study mechanisms of skeletal muscle hypertrophy in rodent disease models Synergist ablation (SA) is a well-established model of mechanical overload-induced hypertrophy in rodents, commonly used toinfer skeletal muscle adaptation to resistance training in humans. Given the critical role of skeletal muscle atrophy in chronicconditions such as neuromuscular, metabolic, and cardiopulmonary disorders, SA represents a promising preclinical tool tostudy muscle hypertrophy mechanisms in pathological states. However, although extensively characterized in healthy animals,the potential applications of SA in disease models remain largely overlooked. This Mini-Review summarizes existing studiesemploying SA in rodent disease models, highlighting the diverse hypertrophic responses observed across conditions, includ-ing Duchenne muscular dystrophy, obesity, diabetes, cancer cachexia, and chronic kidney disease. Although hypertrophygains are generally attenuated in diseased animals compared to healthy controls, SA-induced overload provides valuableinsights into disease-specific regulatory mechanisms, including alterations in intracellular signaling, fiber type transitions, anddisease phenotype. We also discuss the strengths and limitations of SA as a preclinical model for resistance training in dis-ease contexts and propose its broader adoption for mechanistic investigations into skeletal muscle plasticity under pathologi-cal conditions. muscles cancer cachexia exercise metabolic disorders neuromuscular disorders resistance training mišice skeletne mišice mišična hipetrofija trening z uporom true false true Angleški jezik Slovenski jezik Copyright © 2025 The Authors. Neznano 2026-01-13 15:45:57 2026-01-13 15:45:57 2026-01-14 03:53:48 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Soavtorji: Christopher S. Fry, Marco V. Narici, Lee L. Rubin, Feodor D. Price; Opis vira z dne 13. 1. 2026; str. C1389-C1393 iss. 5 Vol. 328 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 2025-03-17 2025-03-24 612.74 1522-1563 10.1152/ajpcell.00076.2025 264573187 2026_01_13_103_Narici_264573187.pdf 2026_01_13_103_Narici_264573187.pdf 1 2E2CBED7D6AABDAB5F1551B231A5DDA1 683d7c6a96295630eeb44d3230b3a81abd801300d5addfee90f8d283e83c6210 ede83adc-f08e-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=38030 https://journals.physiology.org/doi/full/10.1152/ajpcell.00076.2025 1 9398c824-f08e-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=38029 Znanstveno-raziskovalno središče Koper / Centro di Ricerche Scientifiche Capodistria 0 0 0