20.500.12556/DiRROS-25149 Pharmaceutical and biomedical challenges for crew autonomy in health preservation during future exploration missions Humanspace missions beyond Low Earth Orbit (LEO), such as to the Moon and Mars, will require increased crew autonomyinhealthmanagement,duetocommunicationdelaysandlimitedresupply. Thesemissionsposeuniquebiomedicalchallenges,includingradiationexposure,alteredgravity,and prolonged isolation, which can affect physiology and compromise available treatments. This review examines current efforts in pharmaceutical and biomedical strategies to support health preservation during long-duration missions. We discuss technologies needed to assuredrug stability and storage, also considering potential modifications of pharmacokinetics in space, and the potential of nanotechnologies, physical therapies, and in-situ manufacturing. Non-pharmacological tools for diagnostics, trauma care, and tissue regeneration are highlighted for their promise in enhancing medical self-sufficiency. These advances are not only critical for ensuring mission success and crew safety beyond LEO, yet may also translate to healthcare solutions in remote or underserved Earth settings. diagnosis therapeutics diagnoza terapevtika true false true Angleški jezik Slovenski jezik Neznano 2026-01-12 15:54:32 2026-01-12 15:54:32 2026-01-13 03:45:19 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 12. 1. 20256; str. 1-9 Vol. 5 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2025-01-01 616.9 2730-664X 10.1038/s43856-025-01128-7 264399363 26-01-12-264399363-Narici.pdf 26-01-12-264399363-Narici.pdf 1 1046308542111D8CC963903168FF9386 cadec6fb1fbc7591e7143e146de2288cd0361fda6b2424db3bc80e1f0eed923e bc5a71a5-efc6-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37893 https://pmc.ncbi.nlm.nih.gov/articles/PMC12508180/ 1 9ca5f832-efc6-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37892 Znanstveno-raziskovalno središče Koper / Centro di Ricerche Scientifiche Capodistria 0 0 0