20.500.12556/DiRROS-25147 Polymorphisms rs1800587 and rs1143634 of the interleukin-1α gene are associated with the progression of carotid atherosclerosis in Caucasians with type 2 diabetes mellitus Background: Our study was designed to test the possible association between either polymorphisms T889C (rs1800587) or C3954T (rs1143634) of the interleukin-1 alpha (IL-1α) gene with subclinical markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Moreover, the effect of both polymorphisms on progression of carotid atherosclerosis in 3.8-year follow-up was studied. Patients and methods: 595 subjects with T2DM were enrolled in the prospective study. Subclinical markers of carotid atherosclerosis were assessed with ultrasound at the time of recruitment and after 3.8-years. Genotyping of two polymorphisms (rs1800587, rs1143634) was performed with real-time PCR System. Results: The comparison of atherosclerosis parameters was performed with regard to different genotypes of IL-1α rs1800587 and rs1143634 polymorphisms upon enrolment. Multiple linear regression analysis revealed the association of IL-1α rs1143634 on total plaque thickness progression in a 3.8 year follow up. Conclusions: An association between either the IL-1α rs1800587 or rs1143634 and total plaque thickness at the time of recruitment was reported. Additionally, we demonstrated the effect of the IL-1α rs1143634 on total plaque thickness progression in the 3.8-year follow-up in patients with T2DM. carotid atherosclerosis genetic polymorphism interleukin-1 α cross-sectional study true false true Angleški jezik Ni določen V članku navedeno: "This is an open-access article distributed under the terms of the Creative Commons Attribution License." Na spletni strani revije navedeno: "Creative Commons License CC BY-NC-ND 4.0" (https://www.hilarispublisher.com/policies.html. 12. 1. 2026). Neznano 2026-01-12 15:08:34 2026-01-12 15:08:34 2026-01-13 03:45:18 0000-00-00 00:00:00 2016 0 0 Nasl. z nasl. zaslona; Opis vira z dne 29. 12. 2025; str. 1-5 iss. 3, [article no.] 1000113 Vol. 1 2016 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61 2475-3211 10.4172/2475-3211.1000113 263106563 RAZ_Pleskovic_Ales_2016.pdf RAZ_Pleskovic_Ales_2016.pdf 1 38FFD3889F031A0F7589C1DF441B4A9F aa62437e552c060808576c35c8b993152489173a90c99e6f8fd7cac8c65b32f1 d51a1945-efc0-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37889 https://www.hilarispublisher.com/abstract/polymorphisms-rs1800587-and-rs1143634-of-the-interleukin1alpha-gene-are-associated-with-the-progression-of-carotid-ather-26068.html 1 2fda170e-efc0-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37888 Univerzitetni klinični center Ljubljana 0 0 0