20.500.12556/DiRROS-25100 Evaluation of adherence and knowledge retention for adrenaline autoinjector use in Hymenoptera venom-allergic patients with c-KIT p.D816V Introduction: Severe anaphylaxis in patients with clonal mast cell disorders highlights the need for proper use of adrenaline autoinjectors. This study assessed knowledge retention and adherence to autoinjector use in c-KIT p.D816V-positive individuals with hymenoptera venom allergy undergoing venom immunotherapy (VIT) and prescribed two autoinjectors. Methods: Seventy-one VIT patients received personalized autoinjector education, with knowledge assessed at 3, 4 to 12, 12 to 24, and > 24 months. Fifteen patients 5 years post-VIT underwent video-based retraining and were assessed 1 month later. Results: Knowledge retention was 82.3% at 3 months, dropping to 40.0% at 12 to 24 months (p = 0.0160) and 22.2% after 24 months (p = 0.0005), indicating a clear decline over time. Common errors included ignoring the safety cap (16.7%), insufficient injection force, finger injection risk, and upper arm activation (totaling 19.0%). In addition, 19.8% failed to hold the autoinjector in the muscle for 3 seconds, 26.9% did not know to lie supine during anaphylaxis, and 14.3% did not seek emergency help. In the video-retrained group, 80.0% lacked proficiency 1 month later, 73.3% were unaware of the second dose, and 66.7% did not carry their devices. Conclusions: Ongoing tailored education is essential to ensure effective autoinjector use, especially in c-KIT p.D816V-positive venom-allergic patients. Video instruction alone may be insufficient. Hymenoptera autoinjector patient education kožekrilci avtoinjektor izobraževanje bolnikov true false true Dermatovenerologic Society of Slovenia Acta dermatovenerologica Alpina, Pannonica et Adriatica Angleški jezik Slovenski jezik Authors publishing in our journal retain copyright of their work under the Creative Commons Attribution License (CC BY 4.0). This license allows unrestricted use, distribution, and reproduction of the work in any medium, provided the original author(s) and copyright holder(s) are appropriately credited, and the original publication in the journal is properly cited, following established academic practices Neznano 2026-01-09 14:52:05 2026-01-09 14:52:06 2026-01-10 03:48:55 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 23. 12. 2025; str. 171-174 issue 4 Vol. 34 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2025-07-23 2025-10-21 2025-12-01 616-056.43:615.47 1581-2979 10.15570/actaapa.2025.31 262648067 actaapa.2025.31.pdf actaapa.2025.31.pdf 1 E9808DDAF318903F91F1367A8018A663 eb63a063e7e27195d926977c46ff6eaf1a25599abd1daff9f324f61852261b91 6320b4a2-ed62-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37769 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0