20.500.12556/DiRROS-25063 Modulating metabolic health and physiological functions advances in dietary interventions targeting gut microbiota The human gut possesses a highly complex and metabolically functional microbial community. This microbial ecosystem, often termed a “super-organism”, plays a critical function in regulating the host’s metabolic processes, including gut motility, energy absorption, appetite, glucose and lipid metabolism, as well as hepatic fat storage. These metabolic functions of the gut microbiota (GM) play a central role in maintaining host homeostasis and overall metabolic health. This review synthesizes findings from recent clinical and preclinical studies, focusing on the interactions between gut microbiota, metabolic functions, and dietary interventions, to provide an evidence-based overview of current knowledge and future perspectives. Evidence was compiled through a narrative review of studies indexed in PubMed, Scopus, Web of Science, and Google Scholar using prespecified keywords related to gut microbiota, metabolic syndrome, diet, and dysbiosis.Recent advancements in nutritional science and microbiology have highlighted the substantial relation between the GM and multiple pathological conditions, including metabolic syndrome (MetS). A plethora of studies predict that disruptions in the GM, known as dysbiosis, may influence the progression of diabetes, obesity, and cardiovascular diseases (CVDs). Notably, elucidating the contributions of the GM in the pathogenesis of MetS could offer promising avenues for therapeutic interventions. Herein, we review the physiological and metabolic functions of the GM and its connection to MetS pathogenesis, while also highlighting the potential molecular mechanisms underlying these observed associations. Furthermore, we discuss the influence of different dietary approaches on MetS and the impact of nutritional therapeutic strategies to support the development of beneficial gut bacteria and alleviate dysbiosis. By integrating insights from both clinical and preclinical research, this study provides a comprehensive overview of how GM modulation can support metabolic health. The possibility of tailoring nutritional interventions based on individual microbiota profiles represents a promising frontier for personalized and effective approaches to improve metabolic health. metabolic syndrome gut microbiota obesity metabolni sindrom črevesna mikrobiota debelost true false true Angleški jezik Slovenski jezik Neznano 2026-01-08 14:53:55 2026-01-08 14:53:56 2026-01-09 03:52:17 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 16. 12. 2025; str. 1701-1733 Vol. 21 Dec. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.379 1178-203X 10.2147/TCRM.S540144 261749763 RAZ_Rabbani_Syed_Arman_2025.pdf RAZ_Rabbani_Syed_Arman_2025.pdf 1 AEE645D96E4333E4E5251A40E1F03AEA 246b87551531d9476157897b933beda3a456f1934528006eab88c58c53195885 c82d16f1-ec99-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37628 https://www.tandfonline.com/doi/full/10.2147/TCRM.S540144 1 7ab09115-ec99-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37626 Univerzitetni klinični center Ljubljana 0 0 0