20.500.12556/DiRROS-24959 Paraneoplastic hypereosinophilia revealing disseminated colorectal signet ring cell carcinoma Background: Hypereosinophilia, defined as a peripheral blood eosinophil count greater than 1.5 × 109/L, can arise from allergic, infectious, autoimmune, or malignant conditions. In solid tumors, it is rare and most often linked to mucin-secreting carcinomas, while on extremely rare occasions, it accompanies signet ring cell carcinoma, a highly aggressive form of adenocarcinoma. Case Presentation: A 64-year-old woman presented with dyspnea and hypereosinophilia (2.9 × 109/L). She was admitted with suspected eosinophilic pneumonia, but extensive testing was inconclusive. After bone marrow biopsy, her condition deteriorated; histology revealed metastatic signet ring cell carcinoma. PET/CT showed skeletal metastases without apparent local recurrence, although colonoscopy could not be performed to definitively rule it out. Retrospective review uncovered a 2 mm rectal polyp with signet ring cell carcinoma (SRCC) removed two years earlier. Peripheral eosinophilia progressively increased from 0.16 × 109/L ten months earlier to a peak of 4.29 × 109/L one month prior to admission. She died four weeks after discharge. Conclusions: To the best of our knowledge, this case represents one of the smallest reported primary colorectal SRCC lesions (2 mm) presenting with disseminated disease and paraneoplastic hypereosinophilia as the first diagnostic clue. Monitoring peripheral blood eosinophil counts may provide additional insight into disease activity and prognosis in solid tumors. hypereosinophilia signet ring cell carcinoma paraneoplastic syndrome hipereozinofilija pečatnocelični karcinom paraneoplastični sindrom true false true Angleški jezik Slovenski jezik Neznano 2026-01-05 15:19:31 2026-01-05 15:19:31 2026-01-06 03:43:52 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 26. 11. 2025; str. 1-7 issue 4, [article no.] 74 Vol. 7 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 2624-5647 10.3390/gidisord7040074 258733827 RAZ_Rink_Sasa_2025.pdf RAZ_Rink_Sasa_2025.pdf 1 A68007E1AB7427EA4C9B42F219AEF124 94a423b4914b93bf13ea57744b9bd4057fc090cd9d4a06a067d925df3edd7dbe a94b8cc8-ea41-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37395 https://www.mdpi.com/2624-5647/7/4/74 0 b893fb4c-ea41-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37396 Univerzitetni klinični center Ljubljana 0 0 0