20.500.12556/DiRROS-24948 Atypical presentation of cerebral amyloid angiopathy in a 42-year-old man with recurrent lobar hemorrhages and neuropsychiatric symptoms Background: Cerebral amyloid angiopathy (CAA) is a small- and medium-vessel cerebrovascular disease characterized by β-amyloid accumulation within cortical and leptomeningeal arterial walls. Although it most commonly manifests in older individuals as spontaneous lobar hemorrhage, uncommon cases have been reported in younger patients, especially those with risk factors such as previous head trauma, genetic predisposition, or prior exposure to cadaveric dura. Case Description: We describe a diagnostically challenging case of suspected CAA in a 42-year-old man with a history of multiple traumatic brain injuries, prior neurosurgical interventions, neuropsychiatric symptoms, and late-onset seizures. Importantly, during treatment for head trauma in early adulthood, he received a cadaveric dura transplant. Over subsequent years, he developed recurrent lobar hemorrhages and progressive cognitive and behavioral changes, raising concern for an atypical, possibly iatrogenic, form of CAA. Conclusion: This case highlights the need to consider CAA – even in younger patients – when recurrent lobar hemorrhages and neuropsychiatric symptoms occur in the context of relevant risk factors such as previous head trauma or cadaveric dura exposure. We believe that such exposure may underlie this patient’s gradual but persistent neurological and cognitive decline. atypical presentation iatrogenic cerebral amyloid angiopathy neuropsychiatric symptoms true false true Angleški jezik Ni določen Neznano 2026-01-05 12:00:39 2026-01-05 12:00:39 2026-01-06 03:43:48 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 5. 1. 2026; str. 1-5 [article no.] 554 Vol. 16 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 2152-7806 10.25259/SNI_1219_2025 263399683 RAZ_Cepin_Urska_2025.pdf RAZ_Cepin_Urska_2025.pdf 1 5AC348B79A5BB057809AFEFF68E59AE8 a95107f8ef8a6f887064e04fcadb5232c3b7667e0e8c8c6e774ba15b0e1ac5c4 fdeaac03-ea25-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37370 https://surgicalneurologyint.com/surgicalint-articles/atypical-presentation-of-cerebral-amyloid-angiopathy-in-a-42-year-old-man-with-recurrent-lobar-hemorrhages-and-neuropsychiatric-symptoms/ 0 090bc414-ea26-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37371 Univerzitetni klinični center Ljubljana 0 0 0