20.500.12556/DiRROS-24940 Severe traumatic brain injury in early adulthood and cerebral amyloid angiopathy still an overlooked association? Recent research has increasingly recognized a potential link between severe traumatic brain injury (TBI) decades ago and the later development of cerebral amyloid angiopathy (CAA). Although the precise mechanisms linking these two pathologies are incompletely understood, there is a hypothesis that TBI may disrupt amyloid β (Aβ) turnover, with its resultant progressive accumulation within the walls of cerebral vessels. We present the case of a woman with biopsy-confirmed CAA and a history of severe TBI in her early adulthood, who suffered three recurrent intracerebral hemorrhages (ICHs) in the right occipital region, during the course of 1 month. Two of the ICHs necessitated neurosurgical evacuation, and the patient showed a fairly good recovery. This case further extends our previously reported series on the relationship between preceding childhood TBI and the development of CAA. TBI increases amyloid precursor protein production enhancing Aβ levels and promoting chronic blood–brain barrier dysfunction, impairing Aβ clearance. The glymphatic system and intramural periarterial drainage pathways may be compromised following TBI. Additionally, the inflammatory response to TBI promotes vascular oxidative stress and endothelial dysfunction, which may further exacerbate Aβ accumulation. A repeated ICH may be associated with a much worse clinical outcome, necessitating prolonged meticulous observation after the first bout of an ICH in these patients. Further research is needed to clarify TBI's role in CAA progression. case report cerebral amyloid angiopathy early childhood neurology traumatic brain injury vascular true false true Angleški jezik Ni določen Neznano 2026-01-05 09:43:06 2026-01-05 09:43:06 2026-01-06 03:43:47 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 5. 1. 2026; str. 1-4 iss. 1, [article no.] e71555 Vol. 14 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 2050-0904 10.1002/ccr3.71555 263354627 RAZ_Zupan_Matija_2026.pdf RAZ_Zupan_Matija_2026.pdf 1 BCB85E70118A972BEE7D1ED2DC01891A bb68ecdeaef84f228eedc38832dc354f3a080fc58e8843ef23bb4564db72a406 abedd103-ea12-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37355 https://onlinelibrary.wiley.com/doi/10.1002/ccr3.71555 0 b80e4ddb-ea12-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37356 Univerzitetni klinični center Ljubljana 0 0 0