20.500.12556/DiRROS-24893 Assessment of peak inspiratory flow in patients with chronic obstructive pulmonary disease a multicentre, observational, prospective, real-life study Introduction: Patients with chronic obstructive pulmonary disease (COPD) use dry powder inhalers (DPIs) for disease management. DPI effectiveness relies on the patient’s peak inspiratory flow (PIF), which may not always be optimal. We conducted an observational multicentre, prospective, real-life cohort study to determine the prevalence of suboptimal PIF in patients with COPD. Methods: 415 participants (11%, n=47 women, mean age=70±8.7 years, mean forced expiratory volume in 1 s (predicted %)=48.1%) recruited from 17 international centres had baseline PIF recorded with an In-Check Dial device at three resistance levels: (1) low, (2) high and (3) the participant’s maintenance device. We also recorded PIF from participants as they would do at home to verify their proper inhalation technique. Participants underwent spirometry and completed questionnaires (COPD Assessment Test (CAT), Test of Adherence to Inhalers (TAI)-12). Results: Of the 415 participants, 18% of DPI users (n=75) exhibited suboptimal values of PIF (as typical PIF <than what was required for tested inhalers in the study) when evaluated across DPI resistance groups ranging from low (R1) to high (R5) resistance, compared with 14% of participants (n=60) using devices without resistance (R0). Additionally, 14% of study participants were incapable of producing an optimal PIF or unwilling to do so (27%), impacting medication effectiveness. Participants with suboptimal PIF values had higher mean total CAT score (17.7±7) compared with those with optimal PIF values (12.1±7.6). When assessed globally, 37% (n=56) of participants with suboptimal PIF values did not adhere to treatment, highlighting the need for improved patient education and support. Conclusion: Suboptimal PIF is common in COPD, requiring regular assessment and tailored inhalers. chronic obstructive pulmonary disease COPD peak inspiratory flow dry powder inhaler inhaler devices inhaler therapy tailor treatment plans true false true Angleški jezik Ni določen Neznano 2025-12-23 14:04:54 2025-12-23 14:04:54 2025-12-24 04:01:22 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 26. 9. 2025; str. 1-10 iss. 1, [article no.] e002408 Vol. 12 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.2 2052-4439 10.1136/bmjresp-2024-002408 250524675 RAZ_Perugini_Valeria_2025.pdf RAZ_Perugini_Valeria_2025.pdf 1 8B90A749FFBF8B44A9164D150536075A 0b0f1617b8bb23db190925f48f4fca7533d2ee32db04ccfb0cdab20b9f63e6c1 1c72cdd3-e000-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37257 https://bmjopenrespres.bmj.com/content/12/1/e002408 0 2c171850-e000-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37258 Univerzitetni klinični center Ljubljana 0 0 0