20.500.12556/DiRROS-24874 The male hormone reset how GLP-1RAs, lifestyle and testosterone transform obesity-linked problems Introduction: Functional hypogonadism, a manifestation of testosterone deficiency in simultaneously present comorbidities, profoundly impairs quality of life in men with overweight and obesity - yet remains persistently under-recognized in clinical practice. Findings: Lifestyle modification constitutes first-line therapy, while pharmacological and surgical interventions increasingly complement it. Both promote substantial weight loss and may reverse obesity-related hypogonadism; bariatric surgery, in particular, elicits marked rises in circulating testosterone but entails risks of bone demineralization and uncertain long-term reproductive sequelae. Notwithstanding, testosterone deficiency itself represents a key driver of secondary osteoporosis, insulin resistance, anemia, fatigue, and depression as well as sexual symptoms. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have redefined obesity therapy through profound weight reduction and cardiometabolic benefit, yet concomitant losses of lean mass raise concern over sarcopenia and skeletal fragility. Conclusion: This focused review article aims to present a comprehensive update on the latest data concerning combining testosterone therapy with contemporary anti-obesity pharmacotherapy as a new standard of care for obese men with functional hypogonadism, uniting metabolic, vascular, sexual, cognitive, and skeletal benefits within a comprehensive strategy to fortify corporeal resilience and enhance quality of life. male hypogonadism testosterone GLP-1RAs obesity bones osteoporosis true false true Angleški jezik Ni določen Neznano 2025-12-23 08:47:22 2025-12-23 08:47:23 2025-12-24 04:01:12 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 23. 12. 2025; str. 1-21 no. 1, [article no.] 2601423 Vol. 28 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.4 1473-0790 10.1080/13685538.2025.2601423 262655235 RAZ_Groti_Antonic_Kristina_2025.pdf RAZ_Groti_Antonic_Kristina_2025.pdf 1 F9A257B13DC204912B4CAB5008349539 c973ecbccc0142cebffd7333bad2843c8dabba5fcfd3fc44503eeb8d085e3bdd c1658b2a-dfd3-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37204 https://www.tandfonline.com/doi/full/10.1080/13685538.2025.2601423 0 d108ab34-dfd3-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37205 Univerzitetni klinični center Ljubljana 0 0 0