20.500.12556/DiRROS-24854 Intermittent ventricular pre-excitation clinical features and electrophysiological properties Background: Intermittent ventricular pre‐excitation has long been considered a low‐risk marker for sudden death. Accessory pathways (APs) with high‐risk intermittent antegrade conductive properties may exist, but this still represents a gray area in current guidelines. We evaluated differences in risk characteristics between symptomatic and asymptomatic patients with intermittent pre‐excitation (IPX) and those with persistent pre‐excitation (PPX) in a multicenter international registry. Methods: 392 consecutive patients [IPX: 79 (20.15%); PPX: 313 (79.85%)] underwent electrophysiological (EP) study. Data on arrhythmia inducibility (AVRT/AF), AP antegrade conduction properties (ERP/SPERRI), site, and number were collected. Results: No significant differences were found in demographic characteristics and EP features between PPX and IPX patients, including antegrade conductive properties, prevalence of multiple APs, and AP locations, except for AVRT inducibility which was more frequent in IPX group. Similarly, no differences were detected between symptomatic and asymptomatic IPX patients. Conclusions: Except for AVRT inducibility, our study shows no significant differences in demographic and other electrophysiological features between PPX and IPX patients. Likewise, no differences in demographic and EP features were detected between symptomatic and asymptomatic IPX patients. Therefore, intermittent pre‐excitation is an unreliable noninvasive marker of arrhythmic risk and it warrants an invasive risk assessment via EP study. electrophysiological study intermittent ventricular pre‐excitation risk stratification sudden cardiac death Wolff - Parkinson - White syndrome true false true Angleški jezik Ni določen Neznano 2025-12-22 14:27:17 2025-12-22 14:27:18 2025-12-23 03:59:20 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 18. 9. 2025; str. 2818-2826 issue 11 Vol. 36 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 1540-8167 10.1111/jce.70035 249382915 RAZ_Robles_Antonio_Gianluca_2025.pdf RAZ_Robles_Antonio_Gianluca_2025.pdf 1 F2DA37FCEF20576F88D5CAB48D89756D ff442f98d362649ce39c8d7371a3f56a3e3f6f67c31349ad816b0085060254dd 24b80f98-df3a-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37184 https://onlinelibrary.wiley.com/doi/10.1111/jce.70035 0 2d966b68-df3a-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37185 Univerzitetni klinični center Ljubljana 0 0 0