20.500.12556/DiRROS-24811 Hazard identification and characterization of leachable chemicals from plastic products – a new PARC project A recent study has suggested that plastics may contain more than 16,000 chemicals, including additives, processing aids, starting substances, intermediates and Non-Intentionally Added Substances. Plastic chemicals are released throughout the plastic life cycle, from production, use, disposal and recycling. Most of these chemicals have not been studied for potential hazardous properties for humans and in the environment. To refine the risk assessment of these leachable chemicals, additional hazard data are needed. The PlasticLeach project within the EU co-funded Partnership for the Assessment of Risks from Chemicals (PARC) aims to address this data gap by screening several plastic products in daily use. Leachates will be prepared from a number of these plastic items, and these chemical mixtures will be further tested using several test guideline compliant assays and New Approach Methodologies covering both human health and environmental endpoints. The most toxic leachates will be characterized using a non-targeted analysis pipeline to identify chemicals in the leachate. When single chemicals of concern are identified, these will be further tested to determine hazardous properties and identify the respective potency factors to better understand their specific hazard profiles. A tiered approach for hazard testing will be followed. The experimental work will be complemented by in silico toxicological profiling, using publicly available toxicity databases and tools, including Artificial Intelligence tools that cover both human and environmental endpoints. A comprehensive array of endpoints, including cytotoxicity, endocrine disruption, genotoxicity, immunotoxicity, reproductive toxicity and effects related to ecotoxicity will be evaluated. In this paper, we outline the plastic products to be tested and the battery of assays that will be used to identify hazards relevant to both human health and the environment. Data generated from in silico, in vitro, and in vivo approaches will be reported using standardized formats, stored within a centralized repository, and harmonized to adhere to the FAIR data principles (Findable, Accessible, Interoperable, and Reusable). This integrated strategy will not only advance our understanding of the risks associated with plastic-derived chemicals but will also provide critical support for regulatory decision-making and facilitate the development of safer, and more ecofriendly plastic materials in the future. plastics chemicals leachables PARC new approach methodologies hazard assessment toxicity risk assessment plastika kemikalije izlužljive snovi PARC nove metodologije pristopa ocena nevarnosti toksičnost ocena tveganja true false true Angleški jezik Slovenski jezik Neznano 2025-12-19 13:16:15 2025-12-19 13:16:16 2025-12-20 04:07:18 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Soavtorji iz Slovenije: Nina Franko, Marija Sollner Dolenc, Tim Ravnjak, Martina Štampar, Bojana Žegura; Opis vira z dne 1. 12. 2025; 1-12 str. [art. no.] ǂ1719035 Vol. 7 Nov. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2025-11-27 661:615.9 2673-3080 10.3389/ftox.2025.1719035 259032835 https://doi.org/10.3389/ftox.2025.1719035 1 898b7f7a-dcd4-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37112 RAZ_Dirven_Hubert_2025.pdf RAZ_Dirven_Hubert_2025.pdf 1 98108EBD6D0DF21C67D03038BD944350 2da7634ba6269b46c44d7d7d6802bf0e23106157c834e7e1d09d06acb7c5eecc 266f6336-dcd5-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37113 Nacionalni inštitut za biologijo 0 0 0