20.500.12556/DiRROS-24795 Endocrine adaptations to prolonged fasting women who had developed gestational diabetes from physiology, clinical uncertainties, translational challenges to healthspan implications Objectives: Intermittent fasting regimens that include periods of prolonged fasting may mimic certain well-documented benefits of calorie restriction. In this narrative review, we synthesize preclinical and human data on endocrine adaptations during prolonged fasting protocols. Methods: We conducted a structured search of relevant databases, followed by data extraction and synthesis, with a focus on endocrine adaptations during prolonged fasting and their potential implications for healthspan. Results: Across various endocrine axes, prolonged fasting appears to induce a reproducible pattern marked by diminished anabolic signaling and transient activation of potential stress resilience pathways. However, the evidence is limited by small sample sizes, short follow-up durations, methodological heterogeneity, and dependence on surrogate endpoints. Endocrine outcomes are frequently secondary and reported inconsistently. Potential risks include transient hypogonadism, relative hypothyroidism, hypercortisolemia, orthostatic intolerance, electrolyte imbalances, catabolic loss of lean mass, and refeeding challenges. Conclusions: Overall, prolonged fasting activates conserved endocrine mechanisms that may confer plausible cardiometabolic benefits; however, their translation to clinical practice remains speculative. We highlight key knowledge gaps and propose directions for future research in this emerging field. prolonged fasting endocrine adaptations metabolic switch dolgotrajno postenje endokrine prilagoditve presnovni preklop true false true Angleški jezik Slovenski jezik Neznano 2025-12-19 08:55:14 2025-12-19 08:55:15 2025-12-20 04:07:14 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 18. 12. 2025; str. 1-25 iss. 24, [article no.] 3949 Vol. 17 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616.4 2072-6643 10.3390/nu17243949 262140675 RAZ_Herman_Rok_2025.pdf RAZ_Herman_Rok_2025.pdf 1 CC57920731544753AA3BBC1A1FF714F0 ab3c8ff15cfb7ccbac36558e4c614c43ff95b16531780598ee853022090e8f5a 2ea920d5-dcb0-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37079 https://www.mdpi.com/2072-6643/17/24/3949 1 0ff6e00e-dcb0-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=37078 Univerzitetni klinični center Ljubljana 0 0 0