20.500.12556/DiRROS-24741 Nanovaccines to combat drug resistance the next-generation immunisation Nanovaccines to combat drug resistance: the next-generation immunisation Background. The present review envisages the role of nanovaccines to combat the global challenges of antimicrobial resistance. Nanovaccines are a novel formulation comprised of nanomaterials coupled with an immunogenic component to elicit the immune response and provide protection against the desired infectious disease. The nanovaccines with unique physicochemical properties can be more efficient against targeting the desired tissues in the body, aids in prolong circulation to promote antigen-presenting cells to act upon the target antigens. Main content. The present review envisages the development of nanovaccines against antimicrobial-resistant pathogens. The use of nanovaccines can exhibit potent antigenicity with prolonged retention and controlled release to induce both cell- and antibody-mediated responses. Nanovaccines usage is still in the early stages and can be next-generation immunisation for prophylactic and therapeutic efficiency. The future development of nanovaccines against multi-drug-resistant pathogens can explore new avenues. Based on these facts, the present review is designed from the previously reported scientific studies and compiled with the fact that nanovaccines can revolutionise vaccine strategies. The articles were extracted from reputed databases like PubMed, Scopus, and ESCI. The size and conjugating chemistry of nanomaterials can be beneficial in developing novel multi-nanovaccine formulations that can target pools of antimicrobial resistance mechanisms. Conclusion. Overall, the nanovaccines can form one of the best effective modes of targeting multi-drug-resistant pathogens. The nanovaccines can stimulate the innate immune response and generate effective immune-therapeutic novel formulation against infectious pathogens. Based on these facts and considerations, the present article makes an alarming call to develop nanovaccines to counter multi-drug resistance. nanovaccines antimicrobial drug resistance nanomaterials HIV WHO nanocepiva odpornost na antimikrobna zdravila protimikrobna odpornost nanomateriali HIV SZO true false true Springer Nature Egipt Angleški jezik Slovenski jezik © The Author(s) 2023. Neznano 2025-12-16 12:48:43 2025-12-16 12:48:43 2025-12-17 03:58:01 0000-00-00 00:00:00 2023 0 0 Nasl. z nasl. zaslona; Opis vira z dne 23. 8. 2023; str. 1-15 Vol. 9, article no. 64 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2023-06-01 2023-07-25 2023-07-31 620.3 2314-7253 10.1186/s43094-023-00515-y 162054403 https://rdcu.be/dkc76 1 30e420f5-da75-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36972 RAZ_Manju_K._2023.pdf RAZ_Manju_K._2023.pdf 1 C736D6406DBF78DC555E95C76B36DF41 7a3d5a2e53e633d24c6f1b7a317f6fe9f171b52bea490fe3efba06b5ade50cb4 848dd1f2-da75-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36973 Institut Jožef Stefan 0 0 0