20.500.12556/DiRROS-24732 The posterity of Zebrafish in paradigm of in vivo molecular toxicological profiling The aggrandised advancement in utility of advanced day-to-day materials and nanomaterials has raised serious concern on their biocompatibility with human and other biotic members. In last few decades, understanding of toxicity of these materials has been given the centre stage of research using many in vitro and in vivo models. Zebrafish (Danio rerio), a freshwater fish and a member of the minnow family has garnered much attention due to its distinct features, which make it an important and frequently used animal model in various fields of embryology and toxicological studies. Given that fertilization and development of zebrafish eggs take place externally, they serve as an excellent model organism for studying early developmental stages. Moreover, zebrafish possess a comparable genetic composition to humans and share almost 70% of their genes with mammals. This particular model organism has become increasingly popular, especially for developmental research. Moreover, it serves as a link between in vitro studies and in vivo analysis in mammals. It is an appealing choice for vertebrate research, when employing high-throughput methods, due to their small size, swift development, and relatively affordable laboratory setup. This small vertebrate has enhanced comprehension of pathobiology and drug toxicity. This review emphasizes on the recent developments in toxicity screening and assays, and the new insights gained about the toxicity of drugs through these assays. Specifically, the cardio, neural, and, hepatic toxicology studies inferred by applications of nanoparticles have been highlighted. zebrafish cardiotoxicity neurotoxicity hepatotoxicty drug screening navadna cebrica kardiotoksičnost nevrotoksičnost hepatotoksičnost ostanki zdravil true false true Elsevier Nizozemska Angleški jezik Slovenski jezik © 2024 The Authors. Neznano 2025-12-16 12:06:45 2025-12-16 12:06:45 2025-12-17 03:57:58 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Soavtorja iz Slovenije: Ivan Jerman, Raghuraj Singh Chouhan; Opis vira z dne 22. 1. 2024; str. 1-35 Vol. 171, [article no.] 116160 Feb. 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2023-10-04 2024-01-11 2024-01-17 615.9 1950-6007 10.1016/j.biopha.2024.116160 181872643 https://www.sciencedirect.com/science/article/pii/S0753332224000416 1 505bd0a4-da6f-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36953 RAZ_Verma_Suresh_Kr._2024.pdf RAZ_Verma_Suresh_Kr._2024.pdf 1 4949D5AE0E4DB41CA6BFF04E17B47639 55e962cd331bd3be41fb210463c1892098c707b2ff417a180cc98217f258974e bd9f1c84-da6f-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36954 Institut Jožef Stefan 0 0 0