20.500.12556/DiRROS-24726 Red complex periodontal pathogens and their potential role in colorectal carcinogenesis a narrative review Periodontal disease (PD), a chronic inflammatory condition driven by oral microbial dysbiosis, is increasingly implicated in systemic diseases, including colorectal cancer (CRC). The “red complex” bacteria—Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola—play a central role in PD progression and exhibit virulence factors that promote inflammation, immune evasion, and epithelial colonization. A literature search in PubMed, Google Scholar, and ScienceDirect (English and Slovenian, up to September 2025) identified 12 eligible studies. Only original clinical, in vivo, or in vitro research directly addressing red complex pathogens and colorectal cancer was included. The search results showed that most of the literature focuses on the association between Porphyromonas gingivalis and CRC, particularly its role in tumor immune evasion, alteration of the gut microbiota, creation of a pro-inflammatory microenvironment, and promotion of carcinoma cell proliferation. Infection with Porphyromonas gingivalis has also been linked to poorer cancer prognosis. The other red complex bacteria are primarily mentioned in the context of generating a pro-inflammatory microenvironment and contributing to chronic inflammation, which supports tumor growth and survival. periodontal disease red bacterial complex colorectal carcinoma Porphyromonas gingivalis Tannerella forsythia Treponema denticola true false true Angleški jezik Ni določen Neznano 2025-12-15 14:09:02 2025-12-15 14:09:03 2025-12-16 03:44:31 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 16. 10. 20,25; str. 1-12 issue 20, [article no.] 10012 Vol. 26 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616.31 1422-0067 10.3390/ijms262010012 253475075 RAZ_Potocnik_Ursa_2025.pdf RAZ_Potocnik_Ursa_2025.pdf 1 6CCD278D22496C3E78399A5D3B486A05 a9c1b3168372df0f71ed58bfc9d21759138f669e4a25abeb12ed4cc6f6634b1c a0f598a9-d9b7-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36941 https://www.mdpi.com/1422-0067/26/20/10012 0 b5faa015-d9b7-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36943 Univerzitetni klinični center Ljubljana 0 0 0