20.500.12556/DiRROS-24725 Case report agranulocytosis in a child following metamizole use – a diagnostic challenge Objective: This case report describes a young female who developed agranulocytosis with blast cells in peripheral blood following prolonged metamizole use after ankle surgery. Case Report: A 17-year-old female patient was admitted to the Department of Infectious Diseases due to high fever and sore throat. Initial diagnostics revealed agranulocytosis, followed by occurrence of blast cells and left shifted neutrophils in the peripheral blood, in subsequent days. Extensive further diagnostics were performed due to suspicion of leukaemia, which was excluded after flow cytometry and cytogenetic analysis of bone marrow aspirate. After all tests were completed, the patient disclosed that she had been using metamizole for four months following ankle surgery. Conclusion: In cases of agranulocytosis, involving a prolonged history of metamizole use accompanied by the presence of blast cells and granulocyte precursors in peripheral blood, we would recommend an initial diagnostic approach that includes a complete blood count with differential and flow cytometry of peripheral blood. Bone marrow aspiration may be postponed or deemed unnecessary if peripheral blood flow cytometry shows no aberrant populations and there are no other signs of leukaemia. metamizole agranulocytosis leukaemia blast cell flow cytometry metamizol agranulocitoza levkemija blastne celice pretočna citometrija true false true Angleški jezik Slovenski jezik Neznano 2025-12-15 13:55:59 2025-12-15 13:55:59 2025-12-16 03:44:31 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 17. 11. 2025; str. 51-55 no. 1 Vol. 54 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-053.2 1840-2879 10.5644/ama2006-124.472 257420035 RAZ_Pirnat_Aljaz_2025.pdf RAZ_Pirnat_Aljaz_2025.pdf 1 CC232014B761DEE9724B0503E8BFB214 4b4c62337d05074caaf8e0ab3a34a5bb25cd5f3d126aa22e0f76408962a1775a 82e488b8-d9b5-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36938 https://www.ama.ba/index.php/ama/article/view/598 0 8d2b2344-d9b5-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36939 Univerzitetni klinični center Ljubljana 0 0 0