20.500.12556/DiRROS-24704 Genome-wide association study identifies ABCG1 as a susceptibility locus for tick-borne encephalitis Tick-borne encephalitis (TBE) is a viral infection of the central nervous system, caused by the tick-borne encephalitis virus (TBEV) presenting clinically as meningitis, meningoencephalitis, and meningoencephalomyelitis. To investigate genetic susceptibility to TBE, and its severe forms, we conducted a genome-wide association study in the European population comprising 1,600 TBE cases and 9,699 controls. We identified several suggestive (p < 1 × 10−5) intronic and exonic variants in ABCG1, the only gene significantly associated with TBE susceptibility. These variants were shown to influence ABCG1 expression in peripheral blood, a finding corroborated by RNA expression analysis. In vitro inhibition or silencing of ABCG1 significantly reduced TBEV replication in both neuronal cells and macrophages, highlighting the potential role of ABCG1 in TBEV biology. Additionally, we detected a genome-wide significant variant within TEX41, located downstream of ZEB1, associated with severe forms of TBE. These findings provide novel insights into the genetic factors underlying TBE susceptibility and severity. tick-borne encephalitis genome-wide association study GWAS ABCG1 locus klopni meningoencefalitis GWAS ABCG1 lokus true false true Angleški jezik Slovenski jezik Neznano 2025-12-15 09:50:26 2025-12-15 09:50:27 2025-12-16 03:44:28 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 15. 12. 2025; str. 1-10, e1-e5 issue 12, [article no.] 114017 Vol. 28 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616.9 2589-0042 10.1016/j.isci.2025.114017 261339139 Genome-wide_association_study_identifies_ABCG1_as_a_susceptibility_locus_for_tick-borne_encephalitis.pdf Genome-wide_association_study_identifies_ABCG1_as_a_susceptibility_locus_for_tick-borne_encephalitis.pdf 1 11113E4AF431ACB0E7F8F9B24E2516A5 1a67fc9f13ca14c26d71bde011eabca25d116dea3adf1996c6683abfe1327260 5ba2020b-d993-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36891 https://www.sciencedirect.com/science/article/pii/S2589004225022783 0 7b5bf46e-d993-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36892 Univerzitetni klinični center Ljubljana 0 0 0