20.500.12556/DiRROS-24653 Relation of JAK2 V617F allele burden and coronary calcium score in patients with essential thrombocythemia Povezava med alelnim bremenom JAK2 V617F in koronarno kalcifikacijo pri bolnikih z esencialno tormbocitemijo JAK2 V617F (JAK2) mutation is associated with clonal hemopoiesis in myeloproliferative neoplasms as well as with faster progression of cardiovascular diseases. Little is known about the relationship between allele burden and the degree of atherosclerotic alteration of coronary vasculature. We previously reported that carotid artery stiffness progressed faster in patients with JAK2 positive essential thromocythemia (ET) patients. After a four-year follow-up we investigated whether mutation burden of a JAK2 allele correlates with a higher coronary calcium score. Patients and methods. Thirty-six patients with JAK2 positive ET and 38 healthy matched control subjects were examined twice within four years. At each visit clinical baseline characteristics and laboratory testing were performed, JAK2 mutation burden was determined, and coronary calcium was measured. Results. JAK2 allele burden decreased in 19 patients, did not change in 5 patients, and increased in 4 patients. The coronary calcium Agatston score increased slightly in both groups. Overall, there was no correlation between JAK2 allele burden and calcium burden of coronary arteries. However, in patients with the JAK2 mutation burden increase, the coronary calcium score increased as well. Conclusions. The average JAK2 allele burden decreased in our patients with high-risk ET during the four-year period. However, in the small subgroup whose JAK2 mutation burden increased the Agatston coronary calcium score increased as well. This finding, which should be interpreted with caution and validated in a larger group, is in line with emerging evidence that JAK2 mutation accelerates atherosclerosis and can be regarded as a non-classical risk factor for cardiovascular disease. essential thrombocythemia JAK2 V617F mutation JAK2 V617F allele burden true false true Angleški jezik Slovenski jezik Neznano 2025-12-10 13:29:56 2025-12-10 13:29:57 2025-12-11 03:46:37 0000-00-00 00:00:00 2024 0 0 Soavtorji: Ales Blinc, Mojca Bozic Mijovski, Tadej Pajic, Matjaz Vrtovec, Matjaz Sever; str. 565-572 iss. 4 Vol. 58 Dec. 2024 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 61 1318-2099 10.2478/raon-2024-0036 211840515 RAZ_Anzic_Drofenik_Ajda_2024.pdf RAZ_Anzic_Drofenik_Ajda_2024.pdf 1 9830A931211F44999F4613FBEDFDAE55 af419a172f43c7b6ff71d86c65e87e9fb2fac3550ce2a87424816180a72b21f1 36ee90fd-d5c4-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36800 https://sciendo.com/article/10.2478/raon-2024-0036 1 f3997e5c-d5c3-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36798 Univerzitetni klinični center Ljubljana 0 0 0