20.500.12556/DiRROS-24591 Arterial function is preserved in successfully treated patients with psoriasis vulgaris Introduction Endothelial dysfunction is an early precursor of atherosclerosis and is common in patients with psoriasis, presumably primarily due to psoriasis-related inflammation. We investigated endothelial function, arterial stiffness, and circulating markers of endothelial activation in young patients with psoriasis vulgaris of varying severity, all of whom were effectively treated achieving PASI 90. Methods We conducted a cross-sectional study of 80 patients (54 men/26 women, 30–45 years) who were effectively treated with topical therapy, methotrexate, adalimumab, secukinumab or guselkumab, and 20 healthy controls. Endothelial dysfunction was measured by flow-mediated dilation and arterial stiffness was measured by pulse wave velocity and common carotid artery stiffness. The following circulating biomarkers of endothelial activation were measured: ICAM-1, VCAM-1, E- and P-selectin, GDF-15, and TRAIL. Results Endothelial function and arterial stiffness parameters did not differ between patients with effectively treated psoriasis and the control group. Circulating endothelial activation biomarkers did not show relevant differences between the groups of effectively treated patients or controls. Discussion Although cardiovascular disease is the leading cause of morbidity and mortality in patients with psoriasis, effective antipsoriatic treatment appears to slow the progression of atherosclerosis, even when there are cardiovascular risk factors, such as smoking or obesity. This may suggest that antipsoriatic treatment exerts a cardioprotective effect. Conclusions Our results suggest that early and effective treatment of varying-severity psoriasis vulgaris in young patients appears to prevent arterial dysfunction related to psoriasis and consequent cardiovascular risk. psoriasis young patients endothelial function arterial stiffness antipsoriatic treatment true false true Angleški jezik Ni določen Neznano 2025-12-08 13:57:16 2025-12-08 13:57:17 2025-12-09 03:44:02 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 4. 11. 2024; 17 str. iss. 4 Vol. 107 2024 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 61 2047-7163 10.1177/00368504241287893 213565699 RAZ_Merzel_Sabovic_Eva_Klara_2024.pdf RAZ_Merzel_Sabovic_Eva_Klara_2024.pdf 1 927DC2ABF8908F88A972ED8A946069B7 ea19c8226e1bdf42fdd548653994e918d967e25e7b40a94ef6e7e74d15fab3b5 8db9d560-d435-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36691 https://journals.sagepub.com/doi/10.1177/00368504241287893 1 6ec4cd8d-d435-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36690 Univerzitetni klinični center Ljubljana 0 0 0