20.500.12556/DiRROS-24587 Assessment of three criteria to establish borrelial infection in suspected lyme neuroborreliosis Purpose: Diagnosis of (European) Lyme neuroborreliosis has been based on clinical presentation, cerebrospinal fluid (CSF) pleocytosis and demonstration of intrathecal borrelial antibody synthesis (ITBAS) to document Borrelia burgdorferi s. l. infection. It is not known if other criteria to document Borrelia infection may contribute to the diagnosis. Methods: We compared the sensitivity of three individual criteria (ITBAS, CSF Borrelia culture, and the presence of erythema migrans [EM]) to confirm the diagnosis of early Lyme neuroborreliosis in 280 patients≥15 years of age evaluated at a Lyme borreliosis outpatient clinic in Slovenia. The patients had either radicular pain of new onset or involvement of a cranial nerve but without radicular pain, each in conjunction with CSF pleocytosis. Evaluation was of patients who had each of the three confirmatory criteria assessed, and for whom at least one criterion was positive. Results: Analysis of 280 patients, 120 women and 160 men, median age 57 (range 15–84) years, revealed that ITBAS was the most frequently observed positive criterion (85.4%), followed by EM (52.9%), and by a positive CSF Borrelia culture (9.6%). Of the 280 patients, 154 (55%) met only one criterion (43.2% ITBAS only, 10.7% EM only, and 1.1% positive CSF culture only), whereas 42.1% met two criteria. Only 2.9% of patients were positive by all three criteria. Conclusion: Although ITBAS was the most frequent criterion for confirmation for Borrelia infection, the presence of EM alone confirmed an additional 10.7% of patients and a positive CSF Borrelia culture alone added another 1.1%. lyme neuroborreliosis intrathecal borrelial antibody synthesis erythema migrans Borrelia burgdorferi true false true Angleški jezik Ni določen Neznano 2025-12-08 13:30:51 2025-12-08 13:30:51 2025-12-09 03:44:00 0000-00-00 00:00:00 2025 0 0 str. 165-174 iss. 1 Vol. 53 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616.9 0300-8126 10.1007/s15010-024-02338-2 220351747 RAZ_Ogrinc_Katarina_2025.pdf RAZ_Ogrinc_Katarina_2025.pdf 1 BF51A8257ED6D9B2CDDA5399CDBC2BAA 2f009117d2cf2e00e9707527d047c9a5b3c97a567d9e4d523b2a93c4817eb7d5 bfc43997-d431-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36683 https://link.springer.com/article/10.1007/s15010-024-02338-2 0 f4197b7e-d431-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36684 Univerzitetni klinični center Ljubljana 0 0 0