20.500.12556/DiRROS-24586 Association of matrix metalloproteinases polymorphisms with glaucoma risk, glaucoma phenotype, and response to treatment with selective laser trabeculoplasty or latanoprost In open-angle glaucoma, the increase in intraocular pressure (IOP) is caused by an increased resistance to aqueous humour outflow in the trabecular meshwork. Since genetic variability of matrix metalloproteinase (MMP) genes may influence extracellular matrix remodelling, we investigated their association with glaucoma risk and/or response to treatment. The retrospective part of the study included patients with primary open-angle glaucoma and ocular hypertension (OHT); in the prospective part of the study, newly diagnosed patients with POAG or OHT were randomised to receive either latanoprost or selective laser trabeculoplasty (SLT) as the initial treatment. The reduction in IOP was measured 6 weeks after treatment. The following MMP single nucleotide polymorphisms were genotyped: MMP2 rs243865, rs243849, and rs7201; MMP3 rs3025058; MMP9 rs17576, rs17577, rs20544, and rs2250889; MMP14 rs1042704, rs1042704, and rs743257. Logistic regression was used to calculate odds ratios to assess the association between MMP polymorphism and risk of POAG or OHT, glaucoma phenotypes and response to treatment. Only carriers of the MMP3 rs3025058 TT genotype had a significantly higher risk of OHT, more advanced glaucoma, and a higher C/D ratio in the additive and dominant models. None of the investigated MMP polymorphisms were associated with response to treatment with latanoprost and SLT in our study population. glaucoma latanoprost matrix metalloproteinases selective laser trabeculoplasty single nucleotide polymorphisms glavkom latanoprost matrične metaloproteinaze selektivna laserska trabekuloplastika polimorfizmi enega nukleotida true false true Angleški jezik Slovenski jezik Neznano 2025-12-08 13:27:19 2025-12-08 13:27:19 2025-12-09 03:44:00 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 20. 12. 2024; str. 1-17 iss. 24, [article no.] 13464 Vol. 25 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 617.7 1422-0067 10.3390/ijms252413464 220130051 RAZ_Atanasovska_Velkovska_Makedonka_2024.pdf RAZ_Atanasovska_Velkovska_Makedonka_2024.pdf 1 94D3D143E7E9CC0D98F9859519CC14BF abe85b00cd45dd37e3a444adb02a769d27fd5b4183169897d4c73cace3203abc 566f2c2c-d431-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36682 https://www.mdpi.com/1422-0067/25/24/13464 1 3f2b96cf-d431-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36681 Univerzitetni klinični center Ljubljana 0 0 0