20.500.12556/DiRROS-24579 Erythema migrans in patients with post-traumatic splenectomy Information on asplenic Lyme borreliosis (LB) patients with erythema migrans (EM) is lacking. We compared the course and outcome of 26 EM episodes in 24 post-trauma splenectomized patients (median age 51 years) diagnosed at a single clinical center in Slovenia during 1994–2023 with those of 52 age- and sex-matched patients with EM but with no history of splenectomy. All patients were followed for one year. A comparison of pre-treatment characteristics revealed that EM in splenectomized patients was of shorter duration before diagnosis (4 vs. 8 days, p = 0.034) with a smaller EM diameter (10.5 vs. 14 cm, p = 0.046), and more frequently fulfilled criteria for disseminated LB (3/26, 11.5% vs. 0%, p = 0.034). Treatment failure occurred in 5/26 (19.2%) EM episodes in splenectomized patients versus 0/52 in non-splenectomized patients (p = 0.003). The five treatment failure cases were retreated with antibiotic regimens used to treat EM and had complete resolution of all symptoms/signs. In conclusion, our study showed that splenectomized adult patients with EM differ somewhat in presentation and more often have treatment failure compared with non-splenectomized patients with EM. erythema migrans Lyme borreliosis Lyme disease true false true Angleški jezik Ni določen Neznano 2025-12-08 12:21:34 2025-12-08 12:21:35 2025-12-09 03:43:59 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 4. 12. 2024; str. 1-14 iss. 7, [article no.] 1465 Vol. 12 2024 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616.9:579 2076-2607 10.3390/microorganisms12071465 217710595 RAZ_Maraspin-Carman_Vera_2024.pdf RAZ_Maraspin-Carman_Vera_2024.pdf 1 9B9F07506D95E5223A207E535BE7C0BD 9b8babd4a58c6ed8291879860ee5d1cb3f7df808a4b7b64600f4d5b27f931c79 44c4c703-d428-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36668 https://www.mdpi.com/2076-2607/12/7/1465 1 10db66e3-d428-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36667 Univerzitetni klinični center Ljubljana 0 0 0