20.500.12556/DiRROS-24565 Renal response to levosimendan in advanced chronic heart failure patients listed for heart transplantation predicts early postoperative renal function course Background: Beyond its established inotropic effects, levosimendan has been reported to enhance renal function in patients with chronic heart failure. In this study, we investigated whether changes in renal function following levosimendan administration in patients listed for heart transplantation were associated with early post-transplant renal outcomes. Methods: We retrospectively analyzed data from 99 patients with advanced heart failure and renal insufficiency (eGFR < 90 mL/min/1.73 m2) who were listed for heart transplantation and received levosimendan therapy within 1 to 6 months prior to transplantation. Renal function was assessed immediately before and 24 h after levosimendan administration. A favorable renal response was defined as any increase in eGFR at 24 h. Post-transplant renal function was evaluated on postoperative days 1 and 7 using standard renal function parameters. Results: Favorable renal response to levosimendan prior to heart transplantation was present in 73 of 99 patients (74%, Group A), and 26 patients (26%) displayed no increase in eGFR (Group B). In the first week after heart transplantation, we found a significant improvement in renal function in Group A (ΔeGFR: +14 ± 3 mL/min/1.73 m2, p < 0.001), and worsening of renal function in Group B (ΔeGFR: −4 ± 3 mL/min/1.73 m2, p < 0.01). Favorable response to levosimendan prior to heart transplantation was an independent correlate of improved renal function after heart transplantation (p = 0.01). Conclusion: In patients awaiting heart transplantation, improvement in renal function after levosimendan therapy was associated with better early post-transplant renal outcomes. Levosimendan response may thus help identify reversible renal dysfunction and serve as a simple tool for transplant evaluation. heart transplantation renal function levosimendan true false true Angleški jezik Ni določen Neznano 2025-12-05 14:31:06 2025-12-05 14:31:07 2025-12-06 03:47:57 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 19. 9. 2025; str. 1-9 issue 9, [article no.] 357 Vol. 12 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616.1 2308-3425 10.3390/jcdd12090357 249540867 RAZ_Zemljic_Gregor_2025.pdf RAZ_Zemljic_Gregor_2025.pdf 1 03B27A6CE79BB897FFB89BDE39F6B494 d11df26c3b42b226fa86b3ab8f3cfaef70bcdd53130fc4f413096a51143b8fd2 c6daaeed-d1de-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36645 https://www.mdpi.com/2308-3425/12/9/357 0 d7021707-d1de-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36646 Univerzitetni klinični center Ljubljana 0 0 0