20.500.12556/DiRROS-24531 Prevalence of familial hypercholesterolemia in Pakistan a pooled analysis of 1.5 million individuals and comparison with other countries of the region Background: Familial hypercholesterolemia (FH) is an inherited disorder that causes elevated LDL-C levels leading to premature cardiovascular disease but remains underdiagnosed. This study aims to determine the prevalence of FH in Pakistan using data from multiple laboratory networks and compare it with other counties of the region. Methods: The study analyzed lipid profile data from two large laboratory networks in Pakistan, applying Make Early Diagnosis to Prevent Early Death (MEDPED) LDL-C criteria for the general population to identify FH cases. A pooled prevalence estimate of prevalence of FH in Pakistan was calculated by combining the data of studies reporting prevalence in Pakistan. A systematic review was conducted to assess FH prevalence in South and Southeast Asian countries. Results: Analysis of 545,087 individuals (Median age 45 years, 58.2% males) identified 2,911 FH cases [0.55%, 95% confidence interval (CI): 0.53–0.57%), equivalent to a prevalence of 1:182. Pooled analysis with a previous Pakistani study, totaling 1,533,393 subjects, estimated the overall FH prevalence in Pakistan at 1:273 (95% CI: 0.21–0.64%). Prevalence decreased with age, being highest in the familial hypercholesterolemia prevalence cardiovascular disease Pakistan South Asia Southeast Asia screening true false true Angleški jezik Ni določen Neznano 2025-12-04 12:56:25 2025-12-04 12:56:25 2025-12-06 03:40:11 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 21. 5. 2025; 10 str. iss. 1 Vol. 20 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616.1 2211-8179 10.5334/gh.1413 236729091 RAZ_Nawaz_Amjad_2025.pdf RAZ_Nawaz_Amjad_2025.pdf 1 271BFA10CBA041DB9EBF68EFD8D01F6F e9fd8e83d5b7e5591628b670fff1111aeb6381ea1fbcdd1baa2a18657077e5d0 6aa90c3a-d108-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36580 https://globalheartjournal.com/articles/10.5334/gh.1413 1 4578b882-d108-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36579 Univerzitetni klinični center Ljubljana 0 0 0