20.500.12556/DiRROS-24520 Bisphenol A in the urine association with urinary creatinine, impaired kidney function, use of plastic food and beverage storage products but not with serum anti-müllerian hormone in ovarian malignancies Bisphenol A (BPA) is a high-production-volume industrial chemical and component of commonly used plastic products. However, it is also an endocrine-disrupting chemical that can negatively affect human health. It is not yet known whether it is associated with the development of epithelial ovarian cancer (EOC), a severe and highly fatal human disease. Therefore, the purpose of this study was to determine the concentrations of BPA in the urine of women with EOC or epithelial borderline ovarian tumors (EBOTs) using gas chromatography tandem mass spectrometry (GC-MS/MS) and find their possible associations with kidney function at the molecular level, urine and blood biochemical parameters related to metabolism, anti-Müllerian hormone (AMH) (a marker of ovarian reserve/fertility), and lifestyle habits determined via a questionnaire in comparison to healthy controls. The results suggest that the unadjusted or urine-specific-gravity-adjusted BPA levels were significantly increased in women with EOC/EBOT. The unadjusted BPA was significantly positively associated with urinary creatinine (p = 0.007) in all women with EOC/EBOT after adjustment for age, body mass index, and pregnancy using multiple linear regression analysis. This may be related to kidney injury. However, no association was found between urinary BPA and serum AMH levels in women. Women with ovarian malignancies were more exposed to plastic products for storing foods and drinks. Some lifestyle habits, including refilling plastic bottles, correlate with higher urinary BPA levels across the entire cohort of women. When considering EOC or EBOT, it is necessary to consider the potential higher exposure of women to BPA, as reflected in their urine and lifestyle habits. anti-Müllerian hormone kidney function lifestyle habits ovarian cancer thrombocytes urine female exposure true false true Angleški jezik Ni določen Neznano 2025-12-03 14:45:33 2025-12-03 14:45:33 2025-12-04 03:46:33 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira 19. 5. 2025; str. 1-27 iss. 10, aricle no. 4811 Vol. 26 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 61 1422-0067 10.3390/ijms26104811 236382979 RAZ_Sladic_Mateja_2025.pdf RAZ_Sladic_Mateja_2025.pdf 1 B7B35F657B074BB52F61B18328EDC5B7 383cc80035ed46f59c1fed99d82b9a2297edeca17d88a0a0efdb59a9c65a86c2 819de958-d04e-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36555 https://www.mdpi.com/1422-0067/26/10/4811 1 59427f97-d04e-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36554 Univerzitetni klinični center Ljubljana 0 0 0