20.500.12556/DiRROS-24517 Gender disparity in lipid testing among over 0.5 million adults from Pakistan females are tested much later despite higher LDL-cholesterol levels Background and aims: Dyslipidemia is the major risk factor for atherosclerotic cardiovascular disease (ASCVD); therefore, its early diagnosis and treatment is necessary. While previous studies in Pakistan focused on general lipid profiles, investigations into gender disparities in lipid testing remain scarce. Therefore, the present study aims to explore the gender disparity in lipid testing and lipid levels among the adult Pakistani population. Methods: The lipid profile data was obtained from a tertiary care hospital and a diagnostic laboratory with centers across Pakistan. Dyslipidemia was defined based on the criteria provided by the National Cholesterol Education Program (NCEP) guidelines. Gender-based differences in lipid levels were analysed by copula decomposition, breaking down dyslipidemia differences into composition and structure effects. Results: A total of 577,489 adults were included in this study. The highest number of tests (n = 86,709, 14.6%) were conducted in individuals aged between 50 to 54 years. Greater number of males (n = 203,415, 64.3%) were tested before the age of 50 years compared to females (n = 113,030, 35.7%). Conversely, after the age of 50 years, number of tests increased notably among females (n = 137,541, 52.7%) compared to males (n = 123,503, 47.3%; p < 0.001). For all comparisons, significant differences were observed for low density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) levels between males and females (p < 0.001), where average levels of LDL-C, TC and HDL-C were higher in females while average TG levels were higher in males. Conclusion: This study highlights the gender disparity in lipid testing in Pakistan, where females undergo lipid testing later in life, despite higher lipid levels compared to males. cardiovascular disease dyslipidemia gender disparity lipid testing opportunistic testing Pakistan true false true Angleški jezik Ni določen Neznano 2025-12-03 14:18:33 2025-12-03 14:18:33 2025-12-04 03:46:32 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 10. 5. 2025; str. 1-10 iss. 1 Vol. 20 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616.1 2211-8179 10.5334/gh.1401 235443971 RAZ_Nawaz_Amjad_2025.pdf RAZ_Nawaz_Amjad_2025.pdf 1 18CCA7606768FBF637AFCA00DF7F2435 66d77854a0d782f00f4676e6ea86bc4ddcb1c33790560f5addecd0e089369ad5 d7aa4ae8-d04a-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36548 https://globalheartjournal.com/articles/10.5334/gh.1401 1 952d4b95-d04a-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36547 Univerzitetni klinični center Ljubljana 0 0 0