20.500.12556/DiRROS-24516 Postprandial time in tight range with faster insulin aspart compared with standard insulin aspart in youth with type 1 diabetes using automated insulin delivery Aims The aim of this study was to assess postprandial glycaemic outcomes using automated insulin delivery with faster acting insulin aspart (FIA) or standard insulin aspart (SIA) over 4 weeks in youth (aged 10–18 years) with type 1 diabetes. Materials and Methods We undertook a secondary analysis of postprandial glycaemic outcomes from a double-blind, randomised, crossover study comparing FIA to SIA using an investigational version of MiniMed™ 780G. Endpoints included postprandial time in tight range (70–140 mg/dL; TITR), postprandial glucose excursions and peak glucose, and incremental area under curve (iAUC). Results The mean ± SD age of 30 included participants was 15.0 ± 1.7 years, 47% were male, mean HbA1c was 7.5% ± 0.9% (58 ± 9.8 mmol/mol) and the number of meals per day per participant was 3.2 ± 1.2 meals. Overall, the postprandial outcomes were improved with FIA compared with SIA. Mean glucose at the start of the meal was 151 mg/dL in the FIA group and reached a peak glucose of 194 mg/dL, compared with starting level of 151 mg/dL in the SIA group and a peak of 198 mg/dL (difference in excursion: −3.8 mg/dL; 95% confidence interval −5.8 to −1.7; p <0.001). FIA group also had a 1.9% increase in mean TITR (p = 0.02) and a 2.0-mg/dL decrease in mean iAUC (p = 0.003). Differences in outcomes were the most noticeable for breakfast, meals with a larger amount of carbohydrates (>45 g) and participants with lower insulin-to-carbohydrate ratios.Conclusions Faster insulin formulation with AID improved postprandial glycaemic outcomes and could be a useful therapeutical option in youth with type 1 diabetes that have challenges achieving glycaemic targets. postprandial time in tight range standard insulin aspart in youth with type 1 automated insulin delivery true false true Angleški jezik Ni določen Neznano 2025-12-03 14:08:02 2025-12-03 14:08:02 2025-12-04 03:46:31 0000-00-00 00:00:00 2025 0 0 str. 2147-2153 iss. 4 Vol. 27 Apr. 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616.379 1462-8902 10.1111/dom.16211 235096323 RAZ_Dovc_Klemen_2025.pdf RAZ_Dovc_Klemen_2025.pdf 1 733B1B0811B4F1A49D7E9469BA038D3C 7ea2880221bfccf1af7dee4840d8f7ddc3e340d9dd87e6b7192e9467f5277fdc 45daa02e-d049-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36546 https://dom-pubs.onlinelibrary.wiley.com/doi/full/10.1111/dom.16211 1 1c3b9e9b-d049-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36545 Univerzitetni klinični center Ljubljana 0 0 0