20.500.12556/DiRROS-24497 The role of intraoperative monitoring in target selection in deep brain stimulation a single centre study Introduction Intraoperative microelectrode recording (MER) and intraoperative test stimulation may provide vital information for optimal electrode placement and clinical outcome in movement disorders patients treated with deep brain stimulation (DBS). The aims of this retrospective study were to determine (i) how often the planned (imaging based) placements of electrodes were changed due to MER and intraoperative test stimulation in Parkinson’s disease (PD), dystonia and essential tremor (ET) patients; (ii) whether the frequency of repositioning changed over time; (iii) whether patients’ age or disease duration (in PD) influenced the frequency of repositioning. Methods Data on the planned and the final placement of 141 electrodes in 72 consecutive DBS treated patients (52 PD, 11 dystonia, 9 ET) was collected over the first 8 years of DBS implementation in a single center. An association between the rate of electrode repositioning and the patients’ age, disease duration and the time/year of implementation was explored. Results Analysis of all targets showed a change in final electrode placement in 39.7 % (56/141); 39.8 % (41/103) in PD, 40.9 % (9/22) in dystonia and 37.5 % (6/16) in ET. Annual analysis showed a decrease in rate of repositioning between the centre’s first and eighth year (p = 0.013) of implementation. No correlation was found between electrode repositioning rate and patient age (p = 0.42) nor disease duration (p = 0.09) in PD. Conclusion This retrospective analysis confirms the benefit of MER and intraoperative test stimulation during DBS surgery in determining the final electrode position during the early / initial period of implementing the procedure. Our findings show a learning curve in successful preoperative planning in our centre achieved through experience. deep brain stimulation intraoperative monitoringa asleep DBS true false true Angleški jezik Ni določen Neznano 2025-12-02 14:11:50 2025-12-02 14:11:51 2025-12-03 03:42:20 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 2. 4. 2025; str. 1-6 Vol. 12 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 61 2590-1125 10.1016/j.prdoa.2025.100299 231121411 RAZ_Ibrulj_Sandro_2025.pdf RAZ_Ibrulj_Sandro_2025.pdf 1 ADDEE201EEC35EE76E08ADEC9625FAF0 b66f475ccbf3c06d41acb46a16dbb51088aacf7581cb76f4752b3fa4ea1a7ac5 9d4e14c3-cf80-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36509 https://www.sciencedirect.com/science/article/pii/S2590112525000039 0 79589ebd-cf80-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36508 Univerzitetni klinični center Ljubljana 0 0 0