20.500.12556/DiRROS-24477 Current state of epigenetics in giant cell arteritis Focus on microRNA dysregulation Giant cell arteritis (GCA) is a primary systemic vasculitis affecting the elderly, characterized by a granulomatous vessel wall inflammation of large- and medium-sized arteries. The immunopathology of GCA is complex, involving both the innate and adaptive arms of the immune system, where a maladaptive inflammatory-driven vascular repair process ultimately results in vessel wall thickening, intramural vascular smooth muscle cell proliferation, neovascularization and vessel lumen occlusion, which can lead to serious ischemic complications such as visual loss and ischemic stroke. Over the past decade, microRNA (miRNA) dysregulation has been highlighted as an important contributing factor underlying the pathogenesis of GCA. Since current understanding of miRNA involvement in GCA remains largely based on extrapolation of previously determined miRNA functions in vitro or in loss- or gain-of-function studies, an overall insight into the role of miRNA alteration in GCA pathophysiology remains limited. In this narrative review, we summarize the current knowledge on aberrantly expressed miRNAs in GCA and thoroughly discuss the impact of their altered regulatory role in the context of GCA setting. Furthermore, we address challenges and future perspectives in utilization of miRNA-based diagnostic and prognostic biomarkers of GCA in clinical settings. giant cell arteritis epigenetics microRNA inflammation vascular remodeling biomarker gigantocelični arteritis epigenetika mikroRNA vnetje preoblikovanje ožilja biološki označevalec true false true Angleški jezik Slovenski jezik Neznano 2025-12-01 13:13:05 2025-12-01 13:13:06 2025-12-02 03:42:02 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 23. 1. 2025; str. 1-17 iss. 3, [article no.] 103739 Vol. 24 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616.1 1873-0183 10.1016/j.autrev.2024.103739 223554307 RAZ_Bolha_Luka_2025.pdf RAZ_Bolha_Luka_2025.pdf 1 72F80C2F52ADA6CD4B041AD56EA365E4 a2112cd4c632dc28a43d47a407380840f7b34a212f317ed7d0f192c6c8eb479d 352c94da-ceaf-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36471 https://www.sciencedirect.com/science/article/pii/S1568997224002301 1 1a9f0a05-ceaf-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36470 Univerzitetni klinični center Ljubljana 0 0 0