20.500.12556/DiRROS-24454 Temporal variability in the incidence and risk factors for pharyngocutaneous fistula development after total laryngectomy The pharyngocutaneous fistula (PCF) is a pathologic canal connecting the pharyngeal lumen with the skin of the neck occurring after a total laryngectomy (TLE), the removal of the entire larynx. The incidence of PCF ranges from 0% to 80%. Our study aimed to identify the temporal changes in PCF incidence over an extended period and determine the risk factors for increases in the PCF rate. By reviewing patient data from 2004 to 2022, we discovered a total incidence of 26.7%. This study revealed four high-incidence periods, averaging 37.61%, each followed by lower-incidence periods of 19.38%. The surgical wound infection and a history of head and neck cancer along with its related treatments were identified as independent risk factors during most of the high-incidence periods. The continuous monitoring of patients following TLE can assist providers in the better prediction and, consequently, timely management of PCF, ultimately improving patient outcomes after TLE. total laryngectomy fistula incidence fluctuation true false true Angleški jezik Slovenski jezik Neznano 2025-11-28 14:22:11 2025-11-28 14:22:12 2025-11-29 03:56:29 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 3. 1. 2025; str. 1-11 no. 20; ǂ[article no.] ǂ3486 Vol. 16 2024 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 61 2072-6694 10.3390/cancers16203486 220869891 RAZ_Sifrer_Robert_2024.pdf RAZ_Sifrer_Robert_2024.pdf 1 9E1F1320D608DE52899D94E1019D7818 ff91ab1f6f39bfd8abb90195530bbe33fe58bdebf6df01cdaa3d905f219ba165 6560c9f0-cc5d-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36420 https://www.mdpi.com/2072-6694/16/20/3486 1 414e6dc8-cc5d-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36416 Univerzitetni klinični center Ljubljana 0 0 0