20.500.12556/DiRROS-24280 Interplay of anxiety, depression, vascular function, and biomarkers in post-myocardial infarction patients Background and aims: Coronary artery disease (CAD) is a leading cause of mortality. Depression and anxiety are common in CAD patients and negatively affect quality of life, physical functioning, and adherence to cardiac rehabilitation (CR) programs. This study aimed to identify possible associations with clinically relevant parameters, vascular function and blood biomarkers. Methods: Participants were consecutively recruited during cardiac rehabilitation intake visits at the University Medical Centre Ljubljana within 4 months of myocardial infarction (MI). Hospital Anxiety and Depression Scale (HADS) scores were analyzed in relation to endothelial function (assessed with flow-mediated dilation), arterial stiffness, and blood biomarkers (fibrinogen, endocan, and brain-derived neurotrophic factor [BDNF]) in post-MI patients. All vascular and biomarker assessments were performed within 5 days of questionnaire completion and prior to the start of rehabilitation. Results: There were 105 patients included in the study. The median age was 56 years (49–62), and 80.0% of participants were male. Clinically relevant anxiety and depression were present in 29.5% and 21.9% of participants, respectively. Anxiety was significantly associated with younger age, higher body mass index, and increased arterial stiffness, with total HADS scores negatively correlated with age. Endothelial function showed no significant associations with HADS scores. Vital signs showed no significant differences, except for slightly higher systolic blood pressure in those with clinically relevant depression. Fibrinogen levels were significantly higher in participants with anxiety and depression, while endocan and BDNF levels were lower in those with anxiety. Conclusion: Depression and especially anxiety are significantly associated with endothelial function and relevant biomarkers in post-MI patients. However, as HADS is a screening tool and not a diagnostic instrument, and given the study’s observational design, findings reflect associations rather than causality. Routine screening and targeted mental health support within CR programs might improve participation, enhance cardiovascular recovery, and optimize long-term outcomes. These findings underscore the clinical importance of psychological assessment in the early post-MI period and support the integration of mental health evaluation into cardiovascular care. anxiety depression cardiac rehabilitation coronary artery disease myocardial infarction pulse-wave velocity endothelial dysfunction true false true Angleški jezik Ni določen Neznano 2025-11-24 14:32:17 2025-11-24 14:32:18 2025-11-25 04:09:25 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 18. 8. 2025; str. 1-9 [article no.] 1594889 Vol. 16 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616.1 1664-042X 10.3389/fphys.2025.1594889 245821699 RAZ_Kafol_Jan_2025.pdf RAZ_Kafol_Jan_2025.pdf 1 F1AD9202539A790CED071D6CE6DB43AA 58c89fbd188758e4241a285bb3246fa25b03bc5cfa32c5e59cdae168e878f552 245b9afd-c93a-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36172 https://pmc.ncbi.nlm.nih.gov/articles/PMC12146154/pdf/fphys-16-1594889.pdf 1 010320f3-c93a-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36171 Univerzitetni klinični center Ljubljana 0 0 0