20.500.12556/DiRROS-24137 Guideline adherence in febrile children below 3 months visiting European Emergency Departments an observational multicenter study Febrile children below 3 months have a higher risk of serious bacterial infections, which often leads to extensive diagnostics and treatment. There is practice variation in management due to differences in guidelines and their usage and adherence. We aimed to assess whether management in febrile children below 3 months attending European Emergency Departments (EDs) was according to the guidelines for fever. This study is part of the MOFICHE study, which is an observational multicenter study including routine data of febrile children (0–18 years) attending twelve EDs in eight European countries. In febrile children below 3 months (excluding bronchiolitis), we analyzed actual management compared to the guidelines for fever. Ten EDs applied the (adapted) NICE guideline, and two EDs applied local guidelines. Management included diagnostic tests, antibiotic treatment, and admission. We included 913 children with a median age of 1.7 months (IQR 1.0–2.3). Management per ED varied as follows: use of diagnostic tests 14–83%, antibiotic treatment 23–54%, admission 34–86%. Adherence to the guideline was 43% (374/868) for blood cultures, 29% (144/491) for lumbar punctures, 55% (270/492) for antibiotic prescriptions, and 67% (573/859) for admission. Full adherence to these four management components occurred in 15% (132/868, range 0–38%), partial adherence occurred in 56% (484/868, range 35–77%). Conclusion: There is large practice variation in management. The guideline adherence was limited, but highest for admission which implies a cautious approach. Future studies should focus on guideline revision including new biomarkers in order to optimize management in young febrile children. fever children pediatrics guideline emergency care true false true Angleški jezik Ni določen Neznano 2025-11-17 13:31:41 2025-11-17 13:31:41 2025-11-18 03:43:32 0000-00-00 00:00:00 2022 0 0 Nasl. z nasl. zaslona; Opis vira z dne 22. 7. 2025; str. 4199-4209 issue 12 Vol. 181 2022 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616-053.2 1432-1076 10.1007/s00431-022-04606-5 243357955 RAZ_Tan_Chantal_D._2022.pdf RAZ_Tan_Chantal_D._2022.pdf 1 BBD4A655142B2D0DD015BE1BB9E2173E 1714a6e7bddba9134cad9221d68d333b75fa187143f6455c9c4b94239cd36618 8f51fb4a-c3b1-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=35919 https://link.springer.com/article/10.1007/s00431-022-04606-5 0 9abf771a-c3b1-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=35920 Univerzitetni klinični center Ljubljana 0 0 0