20.500.12556/DiRROS-24133 Postnatal levels of glycated albumin and glycated hemoglobin A1c in mothers of large-for-gestational-age newborns Background: Gestational diabetes mellitus (GDM) is an important cause of macrosomia. The value of glycated albumin (GlyA) has been demonstrated to be a useful marker of glycemic control in pregnancy and a predictor of adverse perinatal outcomes. The aim of this study was to investigate the relationship between the postnatal levels of GlyA and glycated hemoglobin A1c (HbA1c) regarding the prenatal diagnosis of GDM in mothers of large-for-gestational-age (LGA) newborns. Methods: The study included mothers and their LGA newborns born between July 2017 and September 2019. The mothers were grouped according to the prenatal diagnosis of GDM, and measurements of GlyA and HbA1c levels in their serum were performed on the first day after delivery of a LGA newborn. Results: A total of 61 LGA newborns and their mothers were enrolled in the study. The median GlyA level was higher, at 16.4% (81.0 µmol/L), whereas the HbA1c level was lower in the group without a prenatal diagnosis of GDM; the differences between groups regarding the GlyA and HbA1c levels were not significant (p > 0.05). The postnatal level of maternal GlyA was positively correlated with birth weight (β = 0.022, p = 0.007), but no correlation with the presence of other adverse perinatal outcomes was found. Conclusion: Mothers of LGA newborns who were not diagnosed with GDM during pregnancy had higher median levels of GlyA and lower HbA1c levels than mothers with prenatal diagnosis of GDM. Values of GlyA in mothers were positively correlated with the birth weight of their newborns but no correlation with other adverse perinatal outcomes was found. Our results indicate the potential value of GlyA for screening of GDM in the last trimester of pregnancy. gestational diabetes mellitus glycated albumin glycated hemoglobin large for gestational age newborn true false true Angleški jezik Ni določen Neznano 2025-11-17 13:08:04 2025-11-17 13:08:04 2025-11-18 03:43:32 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 8. 6. 2025; 8 str. Vol. 12, ǂ[article. no] ǂ1439876 2024 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 618.2/.7 2296-2360 10.3389/fped.2024.1439876 238642435 RAZ_Zeleznik_Mojca_2024.pdf RAZ_Zeleznik_Mojca_2024.pdf 1 06337922779BA363497070B54FE8C231 b7270e78a9cee9ddcb1842f85fd584682485d0eb017b962e2c5e8a4fec5705a4 42741fe5-c3ae-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=35911 https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1439876/full 0 4ee2e697-c3ae-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=35912 Univerzitetni klinični center Ljubljana 0 0 0