20.500.12556/DiRROS-24121 Intestinal involvement in graft versus host disease in children an overview by the ESPGHAN Gastroenterology Committee Graft versus host disease (GVHD) is a complication that frequently occurs afterhaematopoietic stem cell transplantation and concerns many children in paediatrichaematology‐oncology and bone marrow transplantation departments. It can affectvarious organs, with the skin, gastrointestinal tract and liver being the most com-monly involved. To confirm intestinal GVHD and to rule out differential diagnosesendoscopy is frequently needed. Currently, there are no specific consensus rec-ommendations concerning the best method for endoscopic exploration and medicalmanagement of this disease in children, with limited studies available, including alow number of patients. Sigmoidoscopy could be initially proposed under sedation. Ifsigmoidoscopy is normal or if a general anaesthesia is required, colonoscopy andupper endoscopy should be planned, avoiding duodenal biopsy because of the riskof duodenal haematoma. Regarding therapeutic options, corticosteroids are thefirst‐line treatment for GVHD. Ruxolitinib, a Janus kinase inhibitor, is indicated forchildren aged 12 years and older with acute or chronic GVHD who have aninadequate response to corticosteroids or other systemic therapies. Nutritionalsupport has a key role in the management of intestinal GVHD and should beconsidered to guarantee the best possible evolution of intestinal GVHD. GVHD children complication endoscopy haematopoietic stem cell transplantation intestine true false true Angleški jezik Ni določen Neznano 2025-11-14 13:33:12 2025-11-14 13:33:13 2025-11-15 03:41:48 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 2. 6. 2025; str. 246–255 iss 2 Vol. 81 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616-053.2 1536-4801 doi.org/10.1002/jpn3.70087 237958403 RAZ_Vincent_Marina_2025.pdf RAZ_Vincent_Marina_2025.pdf 1 082C107B5596F525C6A2E110572FEB16 a4ea0953b5fcd91c9471c0c4e861d78e5a51a851f0f8728dee5442bf529d6313 905f0aa4-c156-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=35886 https://onlinelibrary.wiley.com/doi/10.1002/jpn3.70087 1 17cb05d1-c156-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=35885 Univerzitetni klinični center Ljubljana 0 0 0