20.500.12556/DiRROS-24104 Teriparatide in sequental treatment of osteoporosis in a patient with spinal muscular atrophy a case report and literature review We report the case of a female patient with spinal muscular atrophy type 3c, low bone mineral density and multiple fragility fractures, successfully treated with teriparatide. She sustained a vertebral fracture at age 35 years while treatment naïve, and additionally, one vertebral fracture as well as an intertrochanteric right hip fracture during the 5-year treatment with oral bisphosphonates. A sequential 2-year treatment with teriparatide followed by a one-year treatment with oral bisphosphonate risedronate resulted in an overall 11-year fracture-free period and stable bone mineral density. Teriparatide is an osteoanabolic medication that effectively reduces vertebral and nonvertebral fractures in postmenopausal, male and glucocorticoid-induced osteoporosis, particularly in individuals at very high risk of fracture. In the context of neuromuscular disease, teriparatide proved effective in the treatment of osteoporosis in Duchenne muscular dystrophy. In contrast, the data for patients with spinal muscular atrophy are lacking. Further studies are needed to assess its role in this population. spinal muscular atrophy osteoporosis fracture spinalna mišična atrofija osteoporoza zlom true false true Angleški jezik Slovenski jezik Neznano 2025-11-12 13:55:15 2025-11-12 13:55:16 2025-11-13 08:28:00 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 2. 7. 2025; str. 1-5 Vol. 19, [article no.] 100253 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616.71:616.12 2666-4593 10.1016/j.dscb.2025.100253 241049603 RAZ_Rakusa_Matej_2025.pdf RAZ_Rakusa_Matej_2025.pdf 1 9C6C77E5EA960F2B5EA5184459F92096 7d81362a40179c39fe791dd5bb7755e44d4f1da77c0e24a0c5a717f940498ff0 0f84bcd1-bfc7-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=35856 https://www.sciencedirect.com/science/article/pii/S2666459325000721?via%3Dihub 1 d7a361a4-bfc6-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=35855 Univerzitetni klinični center Ljubljana 0 0 0