20.500.12556/DiRROS-24059 Dyslipidaemia among children and adolescents in Pakistan a five-year retrospective cohort study based on laboratory data Background: Dyslipidaemia is a signifcant risk factor for cardiovascular diseases, which can manifest early in life. Despite its importance, the prevalence of dyslipidaemia in the paediatric population of Pakistan remains poorly understood. This study uses laboratory data to determine the prevalence of dyslipidaemia and lipid testing practices among Pakistani children and adolescents. Methods: This retrospective cohort study analysed the laboratory data from children and adolescents, aged up to 19 years, who underwent lipid testing. The data was obtained from two centres with collection points all over Pakistan for fve years (March 2019–March 2024). Logistic regression models were used to assess relationships between demographic factors (age, sex and regions/provinces) and lipid profle parameters. Results: Over fve years, 9,787 children and adolescents with a mean age of 13.8±5.1 years underwent lipid testing. Boys accounted for 59.7% of those tested compared to 40.3% of girls (p=0.09). Most tests were conducted in Punjab (81.2%), with minimal representation from Balochistan (0.5%) and Gilgit Baltistan (0.3%). Among tested children and adolescents, 33.3% had elevated total cholesterol, 25.4% high low-density lipoprotein cholesterol, 46.6% low high-density lipoprotein cholesterol, 48.0% abnormal non- high-density lipoprotein cholesterol and 41.7% hypertriglyceridemia. Compared to boys, girls had signifcantly lower odds of abnormal high-density lipoprotein cholesterol (Odds Ratio 0.556, 95% CI 0.511–0.607, p<0.001) and triglyceride levels (Odds Ratio 0.702, 95% CI 0.642–0.767, p<0.001). Conclusion: This study highlights a high prevalence of dyslipidaemia among Pakistani children, with boys more afected than girls. The study also highlights a gender-based inequality in lipid testing where girls appear to be less frequently tested compared to boys. lipid screening paediatric dyslipidaemia burden cardiovascular diseases lipid testing universal screening true false true Angleški jezik Ni določen Neznano 2025-11-10 13:55:18 2025-11-10 13:55:19 2025-11-13 04:02:51 0000-00-00 00:00:00 2025 0 0 Opis vira z dne 27. 5. 2025; Nasl. z nasl. zaslona; str. 1-10 [article no.] 110 Vol. 24 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616.1 1476-511X 10.1186/s12944-025-02529-2 237307395 RAZ_Ain_Quratul_2025.pdf RAZ_Ain_Quratul_2025.pdf 1 6143DD4DAF2C405037F9F4CA678AC0CF e65840f00835f2e89eed58644cca67f75e8dec92757ea6341f68a54b08a19c8b d4994f2e-be34-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=35760 https://lipidworld.biomedcentral.com/articles/10.1186/s12944-025-02529-2 0 1f8fac3d-bfb2-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=35837 Univerzitetni klinični center Ljubljana 0 0 0