20.500.12556/DiRROS-24056 Influence of natural variability and anatomical misalignment on the correlation between segmental myocardial edema and strain in acute myocarditis Background: Acute myocarditis (AM) affects myocardial structure and function, assessed by cardiac magnetic resonance late gadolinium enhancement (CMR-LGE) and speckle tracking echocardiography (STE), respectively; however, the correlation between the two techniques at the segmental level is inconsistent. We studied natural heterogeneity and anatomical orientation mismatch as potential causes of correlation discrepancy. Methods: A total of 30 AM patients underwent left ventricle LGE-CMR and STE measurement, acquiring 18 segmental values depicting edema extent and peak longitudinal strain, respectively. Baseline segmental correlation was compared to average patient segmental correlation and to segmental correlation after spatial resolution reduction achieved by averaging adjacent segments in four successive iterations, where the degree of spatial resolution reduction was evaluated based on the relative decrease in segmental standard deviation. Results: Baseline segmental correlation was weak, i.e., r = 0.24 (p < 0.05) but improved in fitted SLGE and SpLS baseline correlation (r0 = 0.44, p < 0.05) and in average patient correlation (r = 0.55, p < 0.05). Iterative spatial resolution reduction increased the correlation to r1 = 0.49 and r2 = 0.51 and then decreased it to r3 = 0.11 (p < 0.05) and r4 = 0.07 (p > 0.05), with corresponding decreases in segmental standard deviation relative to baseline from σ0 = 12.87 to σ/σ0 = 0.68, 0.51, 0.38, and 0.29 in SLGE values and σ0 = 4.77 to σ/σ0 = 0.57, 0.41, 0.31, and 0.23 in SpLS. Conclusions: Improved correlation in average patients is associated with natural heterogeneity, which indicates a need to develop more robust indicators of ventricular function. The improved correlation in moderate spatial resolution reduction indicates a potential solution for anatomic orientation mismatch between CMR-LGE and STE techniques. acute myocarditis anatomical orientation mismatch cardiac magnetic resonance late gadolinium enhancement natural heterogeneity segmental peak systolic strain spatial resolution reduction speckle tracking echocardiography akutni miokarditis neusklajenost anatomske orientacije magnetna resonanca srca pozno povečanje gadolinija naravna heterogenost segmentna najvišja sistolična napetost zmanjšanje prostorske ločljivosti ehokardiografsko sledenje pegam true false true Angleški jezik Slovenski jezik Neznano 2025-11-10 13:11:43 2025-11-10 13:11:44 2025-11-13 04:02:51 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 28. 3. 2025; str. 1-11 iss. 3, [article no.] 712 Vol. 13 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 612:616.1 2227-9059 10.3390/biomedicines13030712 230632195 RAZ_Awais_Kanza_2025.pdf RAZ_Awais_Kanza_2025.pdf 1 2AC4C01F17FFA0CA9A4D11EED8B5708C ddd7a9708fc04f52b30bd6b09203f38e37a5596459ac0b628be76b3d2a6fc4a1 11f10c11-be2f-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=35755 https://www.mdpi.com/2227-9059/13/3/712 1 6d92db59-be2e-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=35754 Univerzitetni klinični center Ljubljana 0 0 0