20.500.12556/DiRROS-24020 A cross-sectional study of laboratory parameters 5–6 months after the first COVID-19 infection Objectives: Despite extensive study of COVID-19 disease, only a few studies also addressed the aftermath of the disease and potential long-term consequences. The aim of this study was to assess COVID-19 resolution through the cross-sectional analysis of an extensive range of haematological and biochemical laboratory parameters and to find potential markers still associated with disease severity 5-6-months post infection. Methods: In this study, we analysed 92 routine biochemical, haematological and immunological parameters in 75 non-vaccinated patients 5–6 months after recorded first time SARS-CoV-2 infection without reinfection. Demographic and disease severity data were obtained through surveys. Results: The majority of analysed parameters were within the normal reference intervals, however, statistically significant correlations with the disease severity were detected in 15 parameters: B lymphocytes, NK cells, interleukin (IL)-12, IL-1β, cortisol, ferritin, SARS-CoV-2 specific IgG and IgM antibodies, Na, Cl, creatinine, alkaline phosphatase, cholesterol, HbA1c and alpha 2 and beta 2 globulin fractions of the proteinogram. Conclusions: Although most observed parameters returned to their normal reference intervals, significant correlations were still observed with disease severity, that could indicate either the pre-infection baseline state which affected disease outcome or minor remaining alterations in function of certain organs, pertaining their stress or damage during the acute phase of the disease. disease severity laboratory parameters resolution COVID-19 SARS-CoV-2 laboratory diagnosis resnost bolezni laboratorijski parametri resolucija COVID-19 SARS-CoV-2 laboratorijska kemija laboratorijska diagnostika true false true Angleški jezik Slovenski jezik Neznano 2025-11-07 11:52:26 2025-11-07 11:52:26 2025-11-13 04:02:50 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 16. 4. 2025; 12 str. iss. 4, [article no.] e42535 Vol. 11 Feb. 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 542:616.98:578.834 2405-8440 10.1016/j.heliyon.2025.e42535 232905475 RAZ_Zore_Taja_2025.pdf RAZ_Zore_Taja_2025.pdf 1 A811398D1E7AE2686AD470DF7B40A1CB c7c5cfd637f76a9ab258afbbffa0ab7662828e00fbe27c566cd6680497efbc29 dbfc814e-bbc8-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=35696 https://www.sciencedirect.com/science/article/pii/S2405844025009156 1 db7b5e73-bbc7-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=35695 Univerzitetni klinični center Ljubljana 0 0 0