20.500.12556/DiRROS-24005 PET/CT and MR improve interobserver agreement in primary tumor determination for radiotherapy in esophageal squamous cell cancer The aim of the study was to evaluate interobserver variability in the determination of the primary tumor for radiotherapy treatment planning in esophageal squamous cell carcinoma (ESCC). Methods: Sixteen patients with locally advanced ESCC were included in the analysis. In all patients positron emission tomography with computed tomography (PETC/CT) and magnetic resonance (MR) scans for radiotherapy planning were performed. Five experienced radiation oncologists delineated the primary tumor based on CT alone, MR alone, PET/CT, CT with fused MR and PET/CT with fused MR. Mean tumor volumes were calculated for each patient and imaging modality. The generalized conformity index (CIgen) was calculated to assess agreement in tumor determination. Results: The mean tumor volumes and CIgen for CT alone, MR alone, PET/CT, CT with fused MR and PET/CT with fused MR were 33.1 cm3, 30.2 cm3, 38.1 cm3, 31.9 cm3, 36.2 cm3 and 0.59, 0.64, 0.66, 0.63, 0.71, respectively. CIgen was significantly higher using PET/CT with fused MR compared to CT (p < 0.001) and PET/CT (p = 0.002) and using PET/CT compared to CT (alone) (p = 0.003). Conclusions: Our study showed higher agreement in primary tumor determination in ESCC using PET/CT compared to CT alone. Higher agreement was also found using PET/CT with fused MR compared to CT alone and PET/CT. magnetic resonance positron emission tomography squamous cell carcinoma primary tumor magnetna resonanca pozitronsko-emisijska tomografija ploščatocelični rak primarni tumor true false true MDPI, Basel, Switzerland Basel, Switzerland Angleški jezik Slovenski jezik Neznano 2025-11-06 03:38:30 2025-11-26 10:25:40 2025-11-27 03:58:53 0000-00-00 00:00:00 2025 0 Basel 0 Nasl. z nasl. zaslona; Opis vira z dne 31. 3. 2025; str. 690-1-690-10 no. 6 Vol. 15 2025 0000-00-00 Zaloznikova Objavljeno apc 2025-02-07 2025-03-07 2025-03-11 616-006 2075-4418 10.3390/diagnostics15060690 230835203 https://pmc.ncbi.nlm.nih.gov/articles/PMC11941085/ 1 aecd1834-bab9-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=35656 RAZ_Secerov_Ermenc_Ajra_2025.pdf RAZ_Secerov_Ermenc_Ajra_2025.pdf 1 7B39585C29DCF30B8606C6217DDFCA65 81abc4e0082fdf342b31710d4ad99bf09fe511b465e075a387adb5b98ce7acbe 0d55f970-caaa-11f0-94a7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=36266 Onkološki inštitut Ljubljana 0 0 0