20.500.12556/DiRROS-23504 Human hair certified reference material for total mercury, methylmercury, and trace element analyses The National Institute for Environmental Studies (NIES) developed the NIES CRM No. 13-a, a new certified reference material for human hair, using scalp hair from Asian females. This CRM represents a significant advancement in support of global mercury exposure assessments and offers unparalleled reliability and scope compared with existing materials. We aimed to provide a comprehensive overview of the preparation, certification, and application of NIES CRM No. 13-a. In total, 806 bottles (3 g each) were produced, with thorough homogenization ensured through sieving and blending. Certified values for total mercury (1.06 ± 0.07 mg/kg), methylmercury (0.858 ± 0.075 mg/kg), and key trace elements (arsenic, cadmium, lead, selenium, and zinc) were determined through extensive collaborative analyses involving 20 laboratories. Additional reference values were provided for calcium, magnesium, sodium, sulfur, antimony, barium, copper, iron, and manganese. Rigorous stability and homogeneity assessments demonstrated the stability of the CRM for over 10 years and consistency across sample units, even for challenging elements such as selenium. The CRM also includes information values of stable mercury isotope ratios, reflecting their growing importance as exposure tracers. This enhancement in accuracy and traceability facilitates accurate mercury and trace element assessments in human hair, enabling improved biomonitoring of mercury exposure, dietary studies, toxicological evaluations, human health risk evaluations, and regulatory compliance. metilirano živo srebro methylmercury certified reference material true false false Springer Nature Švica Angleški jezik Ni določen © The Author(s) 2025 Neznano 2025-09-05 13:53:25 2025-09-05 13:53:25 2025-10-24 03:54:27 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Soavtorice iz Slovenije: Milena Horvat, Adna Alilović, Polona Klemenčič, Ermira Begu, Marta Jagodic Hudobivnik; Opis vira z dne 9. 6. 2025; str. 277-290 iss. 3 Vol. 30 Jun. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2025-02-26 2025-04-23 2025-05-31 543 1432-0517 10.1007/s00769-025-01637-x 238757891 https://link.springer.com/article/10.1007/s00769-025-01637-x 1 effeb691-8a4e-11f0-9bb7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=34771 RAZ_Yamakawa_Akane_2025.pdf RAZ_Yamakawa_Akane_2025.pdf 1 0882FC693CF0BCB2E0AC01D3717634D4 a3bde2a87bb13cd43505912552a6d60528b4f05f71283cbb78ff0768426677fd 85fa24d1-8a4f-11f0-9bb7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=34773 Institut Jožef Stefan 0 0 0